The second season of the American dramedy-mystery television series Desperate Housewives commenced airing in the United States on September 25, 2005, and concluded on May 21, 2006. The season continues the story of the Wisteria Lane residents, while their seemingly perfect lives in the suburban neighborhood are shaken by the arrival of the mysterious Betty Applewhite. Broadcast in the Sunday night time slot at 9.00 ET, the season aired twenty-four regular episodes, including a two-part season finale. In addition, three clip shows were produced for the season, in order to put the previous events of the show in perspective. "All the Juicy Details" aired before the eleventh episode, detailing the most memorable events of the season's first half, whereas "The More You Know, The Juicier It Gets", which aired before the twentieth episode, prepared the viewers for the highly anticipated season finale. "Time to Come Clean" aired three weeks before the inception of the third season, and reviewed the previous mysteries of the series before introducing the new story lines. The second season had fourteen roles receiving star billing, out of whom eleven were part of the first season's main cast. The main story lines of the season were Susan Mayer's relationship with her former husband, Gabrielle Solis' upcoming motherhood, Lynette Scavo's return to work and the death of Bree Van de Kamp's husband.

Desperate Housewives is an American comedy-drama mystery television series created by Marc Cherry and produced by ABC Studios and Cherry Productions. It aired for eight seasons on ABC from October 3, 2004, until May 13, 2012, for a total of 180 episodes. Executive producer Marc Cherry served as showrunner. Other executive producers since the fourth season included Bob Daily, George W. Perkins, John Pardee, Joey Murphy, David Grossman, and Larry Shaw.