The Destiny module, also known as the U.S. Lab, is the primary operating facility for U.S. research payloads aboard the International Space Station (ISS). It was berthed to the Unity module and activated over a period of five days in February, 2001. Destiny is NASA's first permanent operating orbital research station since Skylab was vacated in February 1974.

The International Space Station (ISS) is a large space station assembled and maintained in low Earth orbit by a collaboration of five space agencies and their contractors: NASA, Roscosmos (Russia), JAXA (Japan), ESA (Europe), and CSA (Canada). The ISS is the largest space station ever built. Its primary purpose is to perform microgravity and space environment experiments.