Destrehan is a census-designated place (CDP) in St. Charles Parish, Louisiana, United States. At the 2020 census, its population was 11,340. It is located on the east bank of the Mississippi River. Destrehan is part of the New Orleans—Metairie—Kenner metropolitan statistical area.

St. Charles Parish is a parish located in the U.S. state of Louisiana. At the 2020 census, its population was 52,549. The parish seat is Hahnville and the most populous community is Luling.