Development of the Commercial Crew Program began in the second round of the Commercial Crew Development (CCDev) program, which was rescoped from a technology development program for human spaceflight to a competitive development program that would produce the spacecraft to be used in the Commercial Crew Program to provide crew transportation services to and from the International Space Station (ISS). To implement the program NASA awarded a series of competitive fixed-price contracts to private vendors starting in 2011. Operational contracts to fly astronauts were awarded in September 2014 to SpaceX and Boeing, and NASA expected each company to complete development and achieve crew rating in 2017. Each company performed an uncrewed orbital test flight in 2019. SpaceX operational flights started in November 2020.

The Constellation program was a crewed spaceflight program developed by NASA, the space agency of the United States, from 2005 to 2009. The major goals of the program were "completion of the International Space Station" and a "return to the Moon no later than 2020" with a crewed flight to the planet Mars as the ultimate goal. The program's logo reflected the three stages of the program: the Earth (ISS), the Moon, and finally Mars—while the Mars goal also found expression in the name given to the program's booster rockets: Ares. The technological aims of the program included the regaining of significant astronaut experience beyond low Earth orbit and the development of technologies necessary to enable sustained human presence on other planetary bodies.