Devil Dogs of the Air is a 1935 Warner Bros. film, directed by Lloyd Bacon and starring James Cagney and Pat O'Brien, playing similar roles as close friends after making their debut as a "buddy team" in Here Comes the Navy. Devil Dogs of the Air was the second of nine features that James Cagney and Pat O'Brien made together. The film's storyline was adapted from a novel by John Monk Saunders.

William Joseph Patrick O'Brien was an American film actor with more than 100 screen credits. Of Irish descent, he often played Irish and Irish-American characters and was referred to as "Hollywood's Irishman in Residence" in the press. One of the best-known screen actors of the 1930s and 1940s, he played priests, cops, military figures, pilots, and reporters. He is especially well-remembered for his roles in Knute Rockne, All American (1940), Angels with Dirty Faces (1938), and Some Like It Hot (1959). He was frequently paired onscreen with Hollywood star James Cagney. O'Brien also appeared on stage and television.