Devil Hole Run is a tributary of Little Fishing Creek in Columbia County, Pennsylvania, in the United States. It is approximately 2.7 miles (4.3 km) long and flows through Pine Township. The stream is mostly surrounded by forested land and it is part of a Locally Significant Area listed on the Columbia County Natural Areas Inventory. It has a single named tributary. Plantlife common in the vicinity of the stream include hemlock trees. Trout inhabit the stream itself.

Little Fishing Creek is a tributary of Fishing Creek in Sullivan County, Lycoming County, and Columbia County, in Pennsylvania, in the United States. It is approximately 23.5 miles (37.8 km) long and flows through eight townships. The watershed of the creek has an area of 68.1 square miles (176 km2). The creek has six named tributaries, of which the largest are Spruce Run and West Branch Run.