Diabolotherium is an extinct genus of megatheriine ground sloth, known from the Late Pleistocene of Peru. Unlike most other extinct mainland sloths, it seems to have been a climber, similar to extinct sloths from the Caribbean. Fossils of the genus were found at the coastal Piedra Escrita site and the Andean Casa del Diablo cave.

Megatheriinae is a subfamily of the Megatheriidae, an extinct family of ground sloths that lived from the Middle Miocene to the Early Holocene.