Dickson County is a county located in the U. S. state of Tennessee. As of the 2010 census, the population was 49,666, its county seat is Charlotte. Dickson County is part of the Nashville-Davidson–Murfreesboro–Franklin, TN Metropolitan Statistical Area. Dickson County is home to Tennessee's oldest courthouse in continuous use, built in 1835; this is the second courthouse in Charlotte as the first one, a log building, was destroyed in the Tornado of 1833, which destroyed all but one building on the courthouse square. October 25, 1803 the Tennessee General Assembly passed a bill creating Dickson County, the 25th of Tennessee's 95 counties, it was formed from parts of Montgomery and Robertson counties, was named for William Dickson, a Nashville physician serving in the United States Congress. Dickson never lived in the county. Dickson was a close friend of President Andrew Jackson. General James Robertson built. Robertson sold his furnace in 1804 to Montgomery Bell, who became one of the state's wealthiest capitalists and industrialists.

The Ruskin Colony was a 250-member, utopian socialist cooperative established in Dickson County in 1894. Located near Tennessee City, it relocated to what is now Ruskin. Internal conflict had brought about the dissolution of the colony by 1899; the Coming Nation, a socialist communalist paper established by Julius Augustus Wayland in Greensburg, was relocated to the Ruskin Colony. It was the forerunner of the Appeal to Reason, which became a weekly political newspaper published in the American Midwest from 1895 until 1922; the Appeal to Reason was known for its politics, giving support to the Farmers' Alliance and People's Party, before becoming a mainstay of the Socialist Party of America following its establishment in 1901. Using a network of motivated volunteers known as the "Appeal Army" to increase its subscription sales, the Appeal's paid circulation climbed to over a quarter million by 1906, half a million by 1910, making it the largest-circulation socialist newspaper in American history.

In July 1917, a mass meeting was held in the Alamo Theatre in Dickson to raise $760 to pay for the surveying of the Bristol to Memphis Highway through Dickson County. The money was raised in less than 15 minutes by donations from those present at the meeting. State highway surveyors began surveying the route on August 14, 1917; the building of this highway put the county along the route known as the “Broadway of America,” Highway 70. On November 4, 1952, Frank G. Clement of Dickson was elected Governor of Tennessee, he served as governor from 1953 to 1959, again from 1963 to 1967. Known for his energetic speaking ability, he delivered the keynote address at the 1956 Democratic National Convention; the Hotel Halbrook, where Clement was born, still stands in Dickson, has been listed on the National Register of Historic Places. According to the U. S. Census Bureau, the county has a total area of 491 square miles, of which 490 square miles is land and 1.4 square miles is water. Dickson County is bordered on the northeast by the Cumberland River.

The Harpeth River passes along the county's eastern border. Ruskin Cave, site of the former socialist colony, is located 8 miles northwest of Dickson. Montgomery County Cheatham County Williamson County Hickman County Humphreys County Houston County Cheatham Lake Wildlife Management Area Hotel Halbrook Railroad and Local History Museum Montgomery Bell State Natural Area Montgomery Bell State Park As of the census of 2000, there were 43,156 people, 16,473 households, 12,173 families residing in the county; the population density was 88 people per square mile. There were 17,614 housing units at an average density of 36 per square mile; the racial makeup of the county was 93.25% European American, 4.58% Black or African American, 0.40% Native American, 0.27% Asian, 0.01% Pacific Islander, 0.47% from other races, 1.01% from two or more races. 1.12 % of the population were Latino of any race. There were 16,473 households out of which 35.60% had children under the age of 18 living with them, 58.30% were married couples living together, 11.50% had a female householder with no husband present, 26.10% were non-families.

22.30% of all households were made up of individuals and 8.90% had someone living alone, 65 years of age or older. The average household size was 2.59 and the average family size was 3.02. In the county, the population was spread out with 26.60% under the age of 18, 8.10% from 18 to 24, 30.70% from 25 to 44, 22.90% from 45 to 64, 11.70% who were 65 years of age or older. The median age was 36 years. For every 100 females, there were 96.20 males. For every 100 females age 18 and over, there were 92.90 males. The median income for a household in the county was $39,056, the median income for a family was $45,575. Males had a median income of $32,252 versus $23,686 for females; the per capita income for the county was $18,043. About 8.10% of families and 10.20% of the population were below the poverty line, including 12.90% of those under age 18 and 11.80% of those age 65 or over. By 2005 the county had a population, 92.0% non-Hispanic white, 4.4% African-American and 1.7% Latino. Dickson County has been a swing county in presidential elections.

The last Democrat to carry this county in a statewide election was Al Gore in 2000. The 12-member county commission is the legislative body of Dickson County. One commissioner is elected from each of the county'

USS Adams was a screw gunboat and the lead ship of the Adams class. Adams was built as wooden-hull, bark-rigged steamer; the ship was laid down in February 1874 at Massachusetts, by Donald McKay. The new ship was commissioned on 21 July 1876 at the Boston Navy Yard, Comdr. John W. Philip in command. Though assigned to the North Atlantic Station, Adams appears to have had no real mission on that station, she spent most of her time in a succession of ports getting ready for permanent assignment. She departed Boston on 6 August, visited Philadelphia between 9 August and 3 September, returned to sea, bound for the Norfolk-Hampton Roads area; the warship tarried there from 6 September to 17 November at which time she got underway for Port Royal, South Carolina. She spent the winter of 1876 and 1877 there. On 9 March 1877, Adams headed back to Norfolk, she remained about five weeks. On 21 April, the warship put to sea for duty on the South Atlantic Station. If her mission on the North Atlantic Station could be regarded as preparatory, her South Atlantic Station assignment might be called transitory.

She arrived on 2 June. Over the next three months, Adams operated along the Brazilian coast, performing one search mission in June and a survey operation in July. On 8 September, she headed south toward the Strait of Magellan. Along the way, the warship called at Buenos Aires, she arrived at the Strait of Magellan on 12 November and remained in the vicinity a month to be available to provide assistance to Chilean government officials at Sandy Point during a mutinous situation there. Adams entered port at Valparaíso, Chile, on the 14th. On the first day of 1878, the warship stood out of Valparaíso bound for Callao and to begin cruising on the Pacific Station, she reached Panama City on 21 February. Adams remained at Panama for three months. On 10 May, the ship embarked the Samoan plenipotentiary, la Mamea, who had just completed negotiations in Washington on a treaty of amity and commerce between the United States and his island kingdom, she set sail to return him and his delegation to Samoa. Adams arrived in Apia harbor on 28 June and stayed for a month to participate in the requisite ceremonies and celebrations.

Between 29 and 30 July, she made the transit from Apia to Pago Pago, the harbor the rights to which the United States had acquired as a result of the recent treaty. Adams returned to Apia for two weeks from 7 to 20 August and got underway to return to the west coast of South America; the warship remained there until late November. On 21 November, Adams stood out of Valparaíso bound for Callao, where she arrived on 2 December for a two-month sojourn, she returned to sea on 5 February 1879 to voyage to Panama. After nearly three months at Panama, Adams headed back to Callao on 11 May and entered that port on the 20th. A week on the 27th, she stood out to sea and laid in a course to Panama on the first leg of a leisurely voyage up the coast via Punta Arenas in Costa Rica, La Unión, El Salvador, Acapulco and Mazatlán in Mexico. On 19 July, the warship arrived in San Francisco and, two days began a lengthy period of repairs at the Mare Island Navy Yard. Adams concluded her long stay at Mare Island on 3 February 1880.

She made the short trip back to San Francisco that same day and began preparations to return to duty on the Pacific Station. The warship headed south. Voyaging by way of Pichilinque Bay and Mazatlan in Mexico, Adams arrived at the Gulf of Dulce in Costa Rica on 29 February and set about establishing a coaling point for ships serving on the Pacific Station. After completing that mission, the warship cruised on station between Costa Rica and Peru until the summer of 1881. On 11 June 1881, she departed Costa Rica, to return to San Francisco, she entered the Mare Island Navy Yard on the 28th. Adams left the yard on 23 August and returned to San Francisco for two days before heading back to the west coast of Latin America on the 25th, she arrived at Panama on 15 September to begin another seven months cruising along the Central American coast. On 11 April 1882, she concluded her assignment on the coasts of South and Central America by departing Panama and setting a course for California; the warship made stops in Mexico at Acapulco and Pichilinque Bay before reentering San Francisco Bay on 11 May.

Two days she made the short trip to the Mare Island Navy Yard for a month of repairs. Back at San Francisco on 11 September, Adams stood out to sea the following day. Instead of heading south to the coasts of Latin America, she pointed her bow north and made for Alaskan waters; the warship reached Sitka on 1 October and began a tour of duty in the northern Pacific of 23 months in duration. Her two main functions in Alaska seem to have been monitoring the seal fur industry and regulating the relations between the native Indian and Eskimo population and the multitude of white traders, prospectors and whalers that had established themselves in the area since the United States purchased the territory from Russia in 1867. Adams had not been on station a month before her commanding officer had to intervene in two incidents involving representatives of the Northwest Trading Company and the native population. Both cases involved the accidental death of an Indian while performing work for th

Histone H2A is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Histones are proteins that package DNA into nucleosomes. Histones are responsible for maintaining the structure of a nucleosome. One chromatin molecule is composed of at least one of each core histones per 100 base pairs of DNA. There are five families of histones known to date. H2A is considered a core histone, along with H2B, H3 and H4. Core formation first occurs through the interaction of two H2A molecules. H2A forms a dimer with H2B. Other histone proteins: H1 H2B H3 H4 Histone H2A is composed of non-allelic variants; the term "Histone H2A" is intentionally non-specific and refers to a variety of related proteins that vary by only a few amino acids. Notable variants include H2A.1, H2A.2, H2A. X, H2A. Z. H2A variants can be explored using "HistoneDB with Variants" database Changes in variant composition occur in differentiating cells; this was observed in differentiating neurons during turnover.

The only variant that remained constant in the neural differentiation was variant H2AZ. H2AZ is a variant that exchanges with conventional H2A core protein. Physically, there are small changes on the surface area of the nucleosome that make the histone differ from H2A. Recent research suggests that H2AZ is incorporated into the nucleosome using a Swr1, a Swi2/Snf2- related adenosine triphosphatase. Another H2A variant, identified is H2AX; this variant has a C-terminal extension. The method of repair this variant employs is non-homologous end joining. Direct DNA damage can induce changes to the sequence variants. Experiments performed with ionizing radiation linked γ- phosphorylation of H2AX to DNA double-strand break. A large amount of chromatin is involved with each DNA double-strand break. Lastly, MacroH2A variant is a variant, similar to H2A; this variant differs from H2A because of the addition of a fold domain in its C-terminal tail. MacroH2A is expressed in the inactive X chromosome in females.

H2A consists of a main globular domain and a long N-terminal tail or C-terminal on one end of the molecule. The N-terminal tail or C-terminal tail is the location of post-translational modification, thus far, researchers have not identified any secondary structures. H2A utilizes a protein fold known as the ‘histone fold.’ The histone fold is a three-helix core domain, connected by two loops. This connection forms a ‘handshake arrangement.’ Most notably, this is termed the helix-turn-helix motif, which allows for dimerization with H2B. The ‘histone fold’ is conserved among H2A at the structural level; the structure of macroH2A variant was exposed through X-ray crystallography. The conserved domain contains a peptidase fold; the function of this conserved domain remains unknown. Research suggests that this conserved domain may function as an anchor site for Xist DNA or it may function as a modifying enzyme. DNA Folding: H2A is important for packaging DNA into chromatin. Since H2A packages DNA molecules into chromatin, the packaging process will affect gene expression.

H2A has been correlated with DNA modification and epigenetics. H2A plays a major role in determining the overall structure of chromatin. Inadvertently, H2A has been found to regulate gene expression. DNA modification by H2A occurs in the cell nucleus. Proteins responsible for nuclear import of H2A protein are importin. Recent studies show that nucleosome assembly protein 1 is used to transport of H2A into the nucleus so it can wrap DNA. Other functions of H2A have been seen in the histone variant H2A. Z; this variant is associated with gene activation and suppression of antisense RNA. In addition, when H2A. Z was studied in human and yeast cells, it was used to promote RNA polymerase II recruitment. Antimicrobial peptide: Histones are conserved eukaryotic cationic proteins present in the cells and are involved in the antimicrobial activities. In vertebrates and invertebrates, Histone H2A variant is reported to be involved in host immune response by acting as antimicrobial peptides. H2A are α-helical molecule, amphipathic protein with hydrophobic and hydrophilic residues on opposing sides that enhances the antimicrobial activity of H2A.

H2A is coded by many genes in the human genome, including: H2AFB1, H2AFB2, H2AFB3, H2AFJ, H2AFV, H2AFX, H2AFY, H2AFY2, H2AFZ Genetic patterns among the different H2A molecules are conserved among variants. The variability in gene expression exists among the regulatory machinery that manages H2A expression. Researchers studied eukaryotic evolutionary lineages of histone proteins and found diversification among the regulatory genes; the greatest differences were observed in core histone gene cis-regulatory sequence motifs and associated protein factors. Variability in gene sequence was seen in bacterial, fungi and mammalian genes. One variant of H2A protein is H2ABbd variant; this variant is composed of a different genetic sequence compared to H2A. The variant functions with transcriptionally active domains. Other variations associated with H2ABbd are located within its C-terminus. H2ABbd has a shorter C-terminal domain compared to the large C-terminal found on H2A; the two C terminals are about 48% identical.

H2ABbd functions with acti

Victor van der Chijs is a Dutch entrepreneur. Since October 1, 2013 he is the President of the Executive Board of the University of Twente, the highest managing body of this university of technology, he holds various advisory positions. Van der Chijs has advised the government of the Netherlands in a range of areas such as international trade and creative industries; the University of Twente is a reputed university of technology that offers research and degree programs in science and technology, information technology, geo-information sciences, social and behavioural sciences. The University of Twente is known for its student-activism and focuses on interdisciplinary collaboration, hence its slogan High Tech, Human Touch. Within one year after his installation, Victor van der Chijs designed a more focused strategy for the future of the university together with students, staff and external stakeholders. Known as Vision 2020, the University’s current strategic direction aims to find innovative solutions for major societal issues.

Van der Chijs’ appointment has contributed to the international profile of the University, with growing numbers in influx of students and researchers. In 2017, Van der Chijs was re-appointed for his second term. Late 2018, the organisation started the strategy formation process entitled Shaping2030, meaning to result in Vision 2020's successor by December 2019. Under Van der Chijs’ leadership, the University of Twente has strengthened its entrepreneurial profile. With over 900 start-ups and spin-off companies, the University of Twente is one of the most entrepreneurial universities in Europe and voted most successful Dutch university in the category knowledge transfer and entrepreneurship. In 2017, the University of Twente was chosen as university with the highest societal impact. In the same year, students chose Twente as Best University of Technology 2018 and second best university of the Netherlands. In keeping with its innovative spirit, the university is committed to maximizing its economic and social contribution to society.

In 2016, Van der Chijs linked Twente to the University Innovation Fellows programme of Stanford University's Hasso Plattner Institute of Design. This programme empowers students to become agents of change at their home institution, advocating for lasting institutional change and creating opportunities for students to engage with innovation, design thinking and creativity. In 2017, Van der Chijs launched a Strategic Business Development unit, which aims to stimulate knowledge transfer and fosters cooperation between the University of Twente and the business community. In 2014, Van der Chijs and Minister of Education Jet Bussemaker opened the DesignLab, which includes the Classroom of the Future; the DesignLab is a creative and cross-disciplinary ecosystem connecting science and society through design. It aims to change the design process and promotes a novel approach to multidisciplinary research and cooperation with business. Van der Chijs has been instrumental in attracting renowned research centers to the university campus.

In January 2017, the Fraunhofer Project Center for Design and Production Engineering was opened on site. The Center’s objective is to meet the pressing demands of smart industry related to design and production engineering in complex high-tech systems. 2017 marked the official opening of the Max Planck – University of Twente Center for Complex Fluid Dynamics. With these two additions, the University has strengthened its position as knowledge hub between Germany and the Netherlands. Van der Chijs is the Chair of the 4TU Federation. In this role, he has been advocating a structural increase in governmental spending on technology and innovation, more broadly, a radical change in approach to how government, knowledge institutes, trade unions, the corporate world can jointly tackle the challenges society is facing in the light of rapid technological changes. Van der Chijs is President of the European Consortium of Innovative Universities; this international consortium consists of 12 research intensive universities with collective emphasis on innovation and societal impact.

Its members share a strong commitment to driving regional development, internationalization, entrepreneurship. Van der Chijs focuses on strengthening the public profile of educational innovation, the link between research and business, entrepreneurial cooperation. Prior to his appointment in April 2017, Van der Chijs acted as Board Member. In July 2019, the European Commission granted the ECIU 5 million euros for a three-year pilot project during which the ECIU universities will pioneer challenge-based instead of degree-based education on a European scale. In March 2018, the University of Twente and Vrije Universiteit Amsterdam announced a joint engineering and technology programme based in Amsterdam as per September 2019. By offering an Amsterdam-based Bachelor’s programme in engineering and technology, Twente and VU, a university of technology and a comprehensive university aim to increase the nation’s total number of engineering graduates capable of tackling the key issues that face society.

Early 2018, Van der Chijs headed a task force installed by 3 of the Dutch economic ‘top sectors’ Creative Industries, Energy and ICT. The task force published recommendations on broadening societal acceptance of measures connected to the foreseen energy transition in The Netherlands; this advice was included in the National Climate Agreement

The Benzie County Courthouse is a historic former courthouse in Beulah, Michigan. It is listed on the National Register of Historic Places. Built in 1912 as a hotel and recreation center, it served as a courthouse until 1976; the building was constructed in 1912. It served as a recreation center and hotel, named "The Grand". In early 1916, Beulah won an election to become the county seat of Benzie County; the former hotel was converted into a courthouse. The jail, nicknamed "The County Root Cellar", was a simple concrete box connected to the courthouse's east end; the county courthouse moved into the Beulah location on June 1, 1916. The courthouse underwent extensive renovations from 1936 through 1938. Benzie County rented the building until 1942 when it purchased the courthouse from Beulah for about $3000. By 1975, the county had raised $615,000 through Federal revenue sharing and the sale of a farm to build a new courthouse. Construction on the new facility began in January 1975, the courthouse moved out of the historic building in 1976.

Since its discontinuation as a courthouse, the building has served a number roles and tenants, including stores, restaurants, an inn, condominiums. The building was designated a Michigan State Historic Site on February 16, 1989, listed on the National Register of Historic Places on June 3, 1996; the courthouse features elements of Spanish Colonial Revival architecture. The building is two stories tall with an attic; the structure features Flemish gables at the sides and the projecting front. A two-story portico with square columns stretches across the front of the building. National Register of Historic Places listings in Benzie County, Michigan List of Michigan State Historic Sites in Benzie County, Michigan Fedynsky, John. Michigan's County Courthouses. University of Michigan Press. ISBN 978-0-472-11728-4

The Artificial Insemination Centre of Quebec is a limited partnership society founded in 1948 located in Saint-Hyacinthe, Canada with the mission of improving through artificial insemination bovine herds used in milk and meat production throughout the province. The CIAQ is the sole bovine sperm production facility in Quebec and is the propriety of the Milk Producers of Quebec, the Quebec Council of Milk Producing Breeds and the Provincial Council of Cattle Amelioration Clubs; the CIAQ provides cattle farmers with bulls from the Ayrshire, Holstein and Brown Swiss milk producing breeds along with other beef breeds. Around 800,000 doses of semen from the CIAQ's banks are used yearly by farmers in Quebec, Nova Scotia and around the world through the Semex Alliance, of which the CIAQ is a founding partner with a 45% stake. At the beginning of the 1940s, the provincial government of Quebec was becoming conscious of the poor yields of milk cattle in most farms. For those at the ministry of agriculture, the new technique of artificial insemination appeared to be an economical and quick method to improve the province's herds, lower production costs and increase revenues.

Lacking the required expertise in its own ranks, the government hired Ernest Mercier, a young agronomist, to complete graduate studies in Cornell University in New York in the field and develop the technique in Quebec. His studies completed, Dr. Mercier founded in 1947 what would become the CIAQ, whose first insemination was conducted the 29 April 1948. From its inception, the CIAQ's main challenge was to set up and maintain an insemination network, implementing a strategy of encouraging farmers organizing themselves in cattle breeding clubs to promote and manage artificial insemination under its oversight; the goal was to provide the CIAQ with herds to test young bulls for potential selection and data from milk producing facility to confirm the success of the offspring of artificially inseminated cows at increasing milk production. The CIAQ conducted research and experimentation to improve artificial insemination techniques, semen conditioning and set up programs for testing young bulls for possible inclusion in its sperm bank.

During its history, the CIAQ underwent several organizational changes. From 1948 to 1981, it was a division of the Ministry of Agriculture and Food of Quebec. Due to increasing demands for its products, it became evident that the CIAQ could no longer be publicly managed by the ministry so in 1981, it was transferred to the now defunct Société Québécoise d'Initiatives Agro-Alimentaires a state-owned corporation. In 1997, the CIAQ teamed-up with three others insemination centres in Canada to form the Semex Alliance whose role is to promote Canadian cattle breeding solutions on the international scene. In 1999, the CIAQ was bought by the PLQ, the CQRL and the CPCAB and became the limited partnership, it today; the genetic improvement of milk and beef producing cattle is at the foundation of the CIAQ's mission. In order to be able to offer producers quality bulls with a known pedigree, a program to test young bulls for becoming potential sperm donors was put together in 1967; when the program was launched, only 3% of Quebec's milk producing cows were registered with a milk quality tracking program and were generating data eligible for consideration in a genetic evaluation initiative.

This number has increased to reach 53% today. Through efforts from the CIAQ, breed associations, the Ministry of Agriculture for promoting genetic testing programs and the cooperation of farmers for testing young potential bulls, 50% of bulls are now tested for inclusion in the CIAQ's sperm banks. Countless bulls have been identified for breeding over the years with some of them reaching fame outside of agricultural field such as Hanoverhill Starbuck, who has fathered at least 200,000 cows throughout the world and can be found in the genealogy of 95% of Canada's Holstein breed cows; the CIAQ is divided between two complexes, one in Saint-Hyacinthe, opened in 1948 and its head office and one in Sainte-Madeleine opened in 1985. In total, the CIAQ houses 670 bulls and keeps in its inventory 11,500,000 doses of semen