Digital Harbor High School is a magnet high school located in Baltimore, Maryland, United States. Occupying the campus of the former Southern High School, it is currently one of two secondary schools and a comprehensive high school that specializes in information technology of Baltimore.

Southern High School was a former public secondary school on Warren Avenue between William Street to the west and Riverside Avenue to the east, in the Federal Hill neighborhood of the northern side of the larger old South Baltimore community on the Whetstone Point peninsula. With historic Fort McHenry from the War of 1812 (1812-1815), to the southeast at the point itself and additional residential areas surrounding the high school in tightly packed rowhouses and streets known as Locust Point and Riverside to the south and southeast along with the restored Otterbein and Sharp-Leadenhall neighborhoods to the west, also just south of the downtown central business district and famed "Inner Harbor" of the City of Baltimore, in Maryland.