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Dili

Dili known as City of Peace, is the capital, largest city, chief port, commercial centre of East Timor. Dili is part of the Timor Leste -- Indonesia -- Australia Growth Triangle. Dili was settled about 1520 by the Portuguese, who made it the capital of Portuguese Timor in 1769, it was proclaimed a city in January 1864. During World War II, Portugal and its colonies remained neutral, but the Allies saw East Timor as a potential target for Japanese invasion, Australian and Dutch forces occupied the island in 1941. On the night of 19 February 1942, the Japanese attacked with a force of around 20,000 men, occupied Dili before spreading out across the rest of the colony. On 26 September 1945, control of the island was returned to Portugal by the Japanese. East Timor unilaterally declared independence from Portugal on 28 November 1975. However, nine days on 7 December, Indonesian forces invaded Dili. On 17 July 1976, Indonesia annexed East Timor, which it designated the 27th province of Indonesia, Timor Timur, with Dili as its capital.

A guerrilla war ensued from 1975 to 1999 between Indonesian and pro-independence forces, during which tens of thousands of East Timorese and some foreign civilians were killed. Media coverage of the 1991 Dili Massacre helped revitalise international support for the East Timorese independence movement. In 1999, East Timor was placed under UN supervision, on 20 May 2002, Dili became the capital of the newly independent Democratic Republic of Timor-Leste. In May 2006, fighting and rioting sparked by conflict between elements of the military caused significant damage to the city and led to foreign military intervention to restore order. Dili lies on the northern coast of the easternmost of the Lesser Sunda Islands, it is the seat of the administration of the municipality of Dili, the administrative entity of the area and includes the island of Atauro and some cities close to Dili city. The city is divided into the Administrative Posts of Nain Feto, Vera Cruz, Dom Aleixo and Cristo Rei and is divided into several sucos, each of, headed by an elected chefe de suco.

18 of the 26 sucos of the four administrative posts are categorised as urban. The municipality has council; the 2010 census recorded a population of 193,563 in the areas of Dili district classified as urban, with a population of 234,331 in the whole district including rural areas such as Atauro and Metinaro. Dili is a melting pot of the different ethnic groups of East Timor, due to the internal migration of young men from around the country in search of work; this has led to a gender imbalance, with the male population larger than the female. Between 2001 and 2004, the population of Dili district grew by 12.58%, with only 54% of the district's inhabitants born in the city. 7% were born in Baucau, 5% each in Viqueque and Bobonaro 4% in Ermera, the remainder in other districts or overseas. Dili has a tropical savanna climate under the Köppen climate classification. Most buildings were damaged or destroyed in the violence of 1999, orchestrated by the Indonesian military and local pro-Indonesia militias.

However, the city still has many buildings from the Portuguese era. E.g. the former Market Hall built around 1930, used as a Congress Centre nowadays. The former Portuguese Governor's office is now the office of the Prime Minister, it was also used by the Indonesian-appointed Governor, by the United Nations Transitional Administration in East Timor. Under Indonesian rule, during which the Portuguese was banned, Portuguese street names like Avenida Marechal Carmona remained unchanged, although they were prefixed with the Indonesian word Jalan or'road'; the Roman Catholic Church at Motael became a focus for resistance to Indonesian occupation. Legacies of Jakarta's occupation are the Church of the Immaculate Conception, seat of the Roman Catholic Diocese of Díli, purportedly the largest cathedral in Southeast Asia, the'Integration Monument', commemorating the Indonesian annexation of the territory in 1976. Featuring a statue of an East Timorese in traditional dress, breaking the chains round his wrists, the monument has not been demolished.

The Cristo Rei of Dili is a 27-metre tall statue of Jesus situated on top of a globe at the end of a peninsula in Dili. It is one of the town's landmarks, it was a present from the government of Indonesia during occupation for the 20th anniversary of East Timor's integration into Indonesia. Schools in Dili include St. Joseph’s High School. There are five International schools in Dili: St Anthony's International School, Timorese owned and managed but teaches in English and uses a modified Australian curriculum. East Timor's major higher education institution, the Universidade Nacional de Timor-Leste is based in Dili. Other universities situated in Dili include the private undergraduate university, Universidade da Paz, Universidade Dili and Dili Institute of Technology, a community-based, non-profit education institution. Dili is served by Presidente Nicolau Lobato International Airport, named after independence leader Nicolau Lobato; this is the only functioning international airport in East Timor, though there are airstrips in Baucau, Suai and

Herald Square Theatre

The Herald Square Theatre was a Broadway theatre in Manhattan, New York City, built in 1883 and closed in 1914. The site is now a highrise designed by H. Craig Severance; the Park Theatre opened in 1883 on the demolished site of the Great New York Aquarium, unrelated to the New York Aquarium. Actor Charles E. Evans, retiring from the stage with cash in hand from the long-running success of A Parlor Match, refurbished the prior Harrigan's Park Theatre as the Herald Square Theatre in 1894, it stood at 1331 Broadway, designed by architects Rose & Stone, with about 1150 seats and with its interior furnished by the interior of the nearby Booth's Theatre, being demolished. Lee Shubert took over the lease of the theatre in 1900, making it the first Broadway theatre owned by The Shubert Organization. Destroyed by fire and rebuilt, in 1911 it became "the first New York theatre to be converted into a silent movie house", but it was demolished only three years as the Garment District expanded, the Broadway theater district migrated north of 40th Street.

The theatre offered a variety of entertainment, from plays, like Shaw's Arms and the Man, to Edwardian musical comedies, like The Girl from Kay's and The Girl Behind the Counter, to operetta, like Reginald De Koven and Harry B. Smith's Rob Roy, it saw the first performance of the George M. Cohan song "You're a Grand Old Flag" in 1906, it was where William Randolph Hearst first saw and met his wife Millicent Willson during her appearance as a "bicycle girl" in 1897. Arms and the Man Napoleon Bonaparte Rob Roy Pudd'nhead Wilson The Heart of Maryland A Parlor Match The Girl From Paris Arizona Dolly Varden The Girl from Kays The Rollicking Girl George Washington, Jr. Widower's Houses The Orchid The Girl Behind the Counter Three Twins The Beauty Spot Tillie's Nightmare Cinema Treasures Listing

Kristen Visbal

Kristen Visbal is an American sculptor living and working in Lewes, Delaware. She specializes in lost-wax casting in bronze. Visbal was born in Montevideo, the daughter of American Ralph Albert and Elizabeth Krystyniak Visbal, she attended the University of Arizona in Tucson 1980-1982 and University of Maryland 1983-1984. She's a Bachelor of Arts summa cum laude at Salisbury State University of 1995, she was an apprentice of lost wax fine art casting at Johnson Atelier Foundry, New Jersey, 1995—1998, is the owner and manager of Visbal Fine Bronze Sculpture in Lewes, Delaware since 1998. Her most well-known work of public art is Fearless Girl, a 50-inch bronze figure installed temporarily on the Bowling Green in Manhattan's Financial District, stirring much international attention and controversy, as it challenges the Charging Bull sculpture of 1989. Visbal has said "The piece is pungent with Girl Power!" Kristen Visbal has since been sued for taking $28,102 from the US Coast Guard Alumni Association to make an Alexander Hamilton statue but failing to produce the work by the contracted deadline.

On February 14, 2019, State Street Global Advisors filed a lawsuit against Kristen Visbal, claiming that she has made and sold replicas of the Fearless Girl statue in violation of her contract with the company. The suit claims the artist made at least three unauthorized Fearless Girl reproductions that could damage the company's global campaign in support of female leadership and gender diversity. Goddess of the Sea, a mermaid with two dolphins framed in water, Myrtle Beach, South Carolina The Cradle of Coaches, a series of ten 120% lifesize statues of celebrated football coaches at Miami University's Cradle of Coaches Plaza in Oxford, Ohio. In Search of Atlantis, a girl swimming with a green sea turtle, Atlantic Beach, Florida The American Cape, a 12 feet 4 inches statue of Alexander Hamilton in Hamilton, Ohio. Sea Express, a man riding on a bottlenose dolphin, Jacksonville Beach, Florida Passing the Torch, a statue of Olympic athlete Bob Hayes, Florida. Girl Chasing Butterflies, Merrill Lynch HQ in Plainsboro, New Jersey, revised version in Hershey Gardens, Pennsylvania Official website

Syracuse Football All-Century Team

The Syracuse Football All-Century Team features the top 44 football players from the 20th century at Syracuse University. The team features a Heisman Trophy winner, nine members of the College Football Hall of Fame, seven other members of the Pro Football Hall of Fame; the All-Century Team includes players from eight different decades. The criteria for selecting the team included all players who impacted Syracuse football with special consideration for those who were either members of the Hall of Fame, were named as All-Americans, or who had played in the NFL. Nominees for the ballot were selected by the prominent figures associated with the Syracuse University football program. Syracuse University Syracuse Orange football team

Phipps (surname)

Phipps is a surname derived from the given name Philip. Phipps family, a family of American entrepreneurs and philanthropists: Henry Phipps, Jr. John Shaffer Phipps Gladys Mills Phipps Lillian Bostwick Phipps Ogden Phipps Ogden Mills Phipps A family of British aristocrats and diplomats: Constantine Phipps, 1st Marquess of Normanby, Lord Lieutenant of Ireland George Phipps, 2nd Marquess of Normanby and politician Henry Phipps, 1st Earl of Mulgrave, Foreign Secretary Constantine Phipps, 1st Baron Mulgrave, Irish peer Constantine Phipps, 2nd Baron Mulgrave, explorer Charles Phipps, naval officer Ramsay Weston Phipps Royal Artillery, military historian Sir Constantine Phipps, diplomat Sir Eric Phipps, diplomat A family of British brewers and politicians from Towcester and Northampton: Pickering Phipps I, founder of Phipps brewery in 1801, mayor of Northampton 1821 John Phipps, mayor of Northampton 1831 John Phipps 2, mayor of Northampton Pickering Phipps II, mayor of Northampton, J. P. MP Pickering Phipps III, High Sheriff of Northamptonshire An English family with origins as clothiers from Westbury, Wiltshire: Thomas Phipps and member of Parliament William Phipps, Governor of Bombay James Phipps, Captain-General of the Royal African Company and Governor of Cape Coast Castle John Lewis Phipps, coffee merchant and member of Parliament Charles Paul Phipps, coffee merchant and member of Parliament Charles Nicholas Paul Phipps, coffee merchant and member of Parliament Joyce Grenfell and actor Simon Wilton Phipps, Bishop of Lincoln Jack Phipps CBE, arts administrator Martin Phipps, composer Bill Phipps known as Reverend William Phipps, Canadian church leader and social justice activist Charles Phipps, several people Ernest Phipps, American singer and Pentecostal preacher Grace Phipps, American actress Jennifer Phipps, Canadian actress Jill Phipps, English animal rights activist Lawrence C.

Phipps, United States Senator from Colorado Mike Phipps, professional football quarterback Polly Phipps, American statistician Steve Phipps, American football coach Spencer Phips and adoptive son of Sir William, lieutenant governor and acting governor of colonial Massachusetts William Phips, colonial governor of Massachusetts William Edward Phipps, Hollywood actor and producer Phipps W. Lake, American politician Bess Phipps Dawson, American painter Philips

Oxidative folding

Oxidative protein folding is a process, responsible for the formation of disulfide bonds between cysteine residues in proteins. The driving force behind this process is a redox reaction, in which electrons pass between several proteins and to a terminal electron acceptor. In prokaryotes, the mechanism of oxidative folding is best studied in Gram-negative bacteria; this process is catalysed by protein machinery residing in the periplasmic space of bacteria. The formation of disulfide bonds in a protein is made possible by two related pathways: an oxidative pathway, responsible for the formation of the disulfides, an isomerization pathway that shuffles incorrectly formed disulfides; the oxidative pathway relies, just on a protein relay. The first member of this protein relay is a small periplasmic protein called DsbA, which has two cysteine residues that must be oxidized for it to be active; when in its oxidized state, the protein is able to form disulfide bonds between cysteine residues in newly synthesized, yet unfolded proteins by the transfer of its own disulfide bond onto the folding protein.

After the transfer of this disulfide bond, DsbA is in a reduced state. For it to act catalytically again, it must be reoxidized; this is made possible by a 21 kDa inner membrane protein, called DsbB, which has two pairs of cysteine residues. A mixed disulfide is formed between a cysteine residue of DsbB and one of DsbA; this cross-link between the two proteins is broken by a nucleophilic attack of the second cystein residue in the DsbA active site. On his turn, DsbB is reoxidized by transferring electrons to oxidized ubiquinone, which passes them to cytochrome oxidases, which reduce oxygen; as molecular oxygen serves as the terminal electron acceptor in aerobic conditions, oxidative folding is conveniently coupled to it through the respiratory chain. In anaerobic conditions however, DsbB passes its electrons to menaquinone, followed by a transfer of electrons to fumarate reductase or nitrate reductase. For proteins that contain more than one disulfide bond, it is important that incorrect disulfide bonds become rearranged.

This is carried out in the isomerization pathway by the protein DsbC, that acts as a disulfide isomerase. DsbC is a dimer, consisting of two identical 23 kDa subunits and has four cysteine residues in each subunit. One of these cysteines attacks an incorrect disulfide in a misfolded protein and a mixed disulfide is formed between DsbC and this protein. Next, the attack of a second cysteine residue results in the forming of a more stable disulfide in the refolded protein; this may be a cysteine residue either from the earlier misfolded protein or one from DsbC. In the last case, DsbC must be reduced in order to play another catalytic role. There is a second isomerase that can reorganize incorrect disulfide bonds; this protein is called DsbG and it is a dimer that serves as a chaperone. To fulfil their role as isomerases, DsbC and DsbG must be kept in a reduced state; this is carried out by DsbD. Thioredoxin, which itself is reduced by thioredoxin reductase and NADPH, ensures the reduction of the DsbD protein.

Because these two pathways coexist next to each other in the same periplasmic compartment, there must be a mechanism to prevent oxidation of DsbC by DsbB. This mechanism indeed exists as DsbB can distinguish between DsbA and DsbC because this latter has the ability to dimerize. A similar pathway is followed in eukaryotes, in which the protein relay consists of proteins with analogous properties as those of the protein relay in Gram-negative bacteria. However, a major difference between prokaryotes and eukaryotes is found in the fact that the process of oxidative protein folding occurs in the endoplasmatic reticulum in eukaryotes. A second difference is that in eukaryotes, the use of molecular oxygen as a terminal electron acceptor is not linked to the process of oxidative folding through the respiratory chain as is the case in bacteria. In fact, one of the proteins involved in the oxidative folding process uses a flavin-dependent reaction to pass electrons directly to molecular oxygen. A homolog of DsbA, called protein disulfide isomerase, is responsible for the formation of the disulfide bonds in unfolded eukaryotic proteins.

This protein has two thioredoxine-like active sites. By transferring the disulfide bond between these two cysteine residues onto the folding protein it is responsible for the latter’s oxidation. In contrast to bacteria, where the oxidative and isomerization pathways are carried out by different proteins, PDI is responsible for the reduction and isomerization of the disulfide bonds. For PDI to catalyse the formation of disulfide bonds in unfolded proteins, it must be reoxidized; this is carried out by an ER membrane-associated protein, Ero1p, no homolog of DsbB. This Ero1p protein forms a mixed disulfide with PDI, resolved by a nucleophilic attack of the second cystein residue in one of the active sites of PDI; as result, oxidized PDI is obtained. Ero1p itself is oxidized by transferring electrons to molecular oxygen; as it is an FAD-binding protein, this transfer of electrons is favoured when Ero1p is bound to FAD. A transport system that imports FAD into the ER lumen has been described in eukaryotes.

Furthermore, it has been shown that the ability to reduce or rearrange incorrect disulfide bonds in missfolded proteins is provided by the oxidation of reduced glutathione to oxidized glutathione. Because of the property of Ero1p to transfer electrons directly to molecular oxygen via a flavin-dependent reaction, its activi