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Diphenhydramine is an antihistamine used to treat allergies. It can be used for insomnia, symptoms of the common cold, tremor in parkinsonism, nausea, it is applied to the skin. Maximal effect is around two hours after a dose, effects can last for up to seven hours. Common side effects include poor coordination and an upset stomach, its use is not recommended in the elderly. There is no clear risk of harm, it works by blocking certain effects of histamine. Diphenhydramine is an anticholinergic. Diphenhydramine was first made by George Rieveschl and came into commercial use in 1946, it is available as a generic medication. The wholesale price in the developing world as of 2014 is about US$0.01 per dose. In the United States, it costs less than US$25 for a typical month's supply, it is sold among others. In 2016 it was the 210th most prescribed medication in the United States with more than 2 million prescriptions. Diphenhydramine is a first-generation antihistamine used to treat a number of conditions including allergic symptoms and itchiness, the common cold, motion sickness, extrapyramidal symptoms.

Diphenhydramine has local anesthetic properties, has been used as such in people allergic to common local anesthetics such as lidocaine. Diphenhydramine is effective in treatment of allergies; as of 2007, it was the most used antihistamine for acute allergic reactions in the emergency department. By injection it is used in addition to epinephrine for anaphylaxis, its use for this purpose had not been properly studied as of 2007. Its use is only recommended. Topical formulations of diphenhydramine are available, including creams, lotions and sprays; these are used to relieve itching and have the advantage of causing fewer systemic effects than oral forms. Diphenhydramine is used to treat Parkinson's disease–like extrapyramidal symptoms caused by antipsychotics; because of its sedative properties, diphenhydramine is used in nonprescription sleep aids for insomnia. The drug is an ingredient in several products sold as sleep aids, either alone or in combination with other ingredients such as acetaminophen in Tylenol PM or ibuprofen in Advil PM.

Diphenhydramine can cause minor psychological dependence. Diphenhydramine can cause sedation and has been used as an anxiolytic. Diphenhydramine has antiemetic properties, which make it useful in treating the nausea that occurs in vertigo and motion sickness. Diphenhydramine is not recommended for people older than 60 or children under the age of six, unless a physician is consulted; these populations should be treated with second-generation antihistamines such as loratadine, fexofenadine, cetirizine and azelastine. Due to its strong anticholinergic effects, diphenhydramine is on the Beers list of drugs to avoid in the elderly. Diphenhydramine is category B in the FDA Classification of Drug Safety During Pregnancy, it is excreted in breast milk. Paradoxical reactions to diphenhydramine have been documented, in particular among children, it may cause excitation instead of sedation. Topical diphenhydramine is sometimes used for people in hospice; this use is without indication and topical diphenhydramine should not be used as treatment for nausea because research does not indicate this therapy is more effective than alternatives.

The most prominent side effect is sedation. A typical dose creates driving impairment equivalent to a blood-alcohol level of 0.10, higher than the 0.08 limit of most drunk-driving laws. Diphenhydramine is a potent anticholinergic agent; this activity is responsible for the side effects of dry mouth and throat, increased heart rate, pupil dilation, urinary retention, and, at high doses, hallucinations or delirium. Other side effects include motor impairment, flushed skin, blurred vision at nearpoint owing to lack of accommodation, abnormal sensitivity to bright light, difficulty concentrating, short-term memory loss, visual disturbances, irregular breathing, irritability, itchy skin, increased body temperature, temporary erectile dysfunction, excitability, although it can be used to treat nausea, higher doses may cause vomiting; some individuals experience an allergic reaction to diphenhydramine in the form of hives. Conditions such as restlessness or akathisia can worsen from increased levels of diphenhydramine with recreational dosages.

Normal doses of diphenhydramine, like other first generation antihistamines, can make symptoms of restless legs syndrome worse. As diphenhydramine is extensively metabolized by the liver, caution should be exercised when giving the drug to individuals with hepatic impairment. Anticholinergic use in life is associated with an increased risk for cognitive decline and dementia among older people. Diphenhydramine overdose symptoms may include: Acute poisoning can be fatal, leading to cardiovascular collapse and death in 2–18 hours, in general is treated using a symptomatic and supportive approach. Diagnosis of toxicity is based on history and clinical presentation, in general specific levels are not useful. Several levels of evidence indicate diphenhydramine can block the delayed rectifier potassium channel and, as a consequence, prolong the QT interval, leading to cardiac arrhythmias such as torsades de pointes. No specific antidote for diphenhy

Louis de Beaufort

Louis de Beaufort was a French-Dutch historian best known for his critical approach to the history of Rome. His brother was Daniel Cornelius de Beaufort. Born in The Hague to a French family of Huguenots, he lived in Utrecht and Leiden and worked as a personal tutor to the Prince of Hesse-Hombourg while at Leiden University. In 1738 he published at Utrecht the Dissertation sur l'incertitude des cinq prèmiers siècles de l'histoire romaine, in which he questioned the value of the classical sources of the highest repute, such as Livy and Dionysius of Halicarnassus, for writing the history of the origins of ancient Rome, pointed out by what methods and by the aid of what documents a scientific basis might be given to its history. While this was not an unprecedented argument, Beaufort made his case forcefully and pushed against the traditional and less critical approaches adopted by esteemed historians of the time such as Charles Rollin. A German, Christopher Saxius, endeavoured to refute Beaufort's argument in a series of articles published in vols. i.-iii. of the Miscellanea Liviensia.

Beaufort replied by some brief and ironic Remarques in the appendix to the second edition of his Dissertation. He was elected a Fellow of the Royal Society in October 1746 and would move to Maastricht where he died in 1795, he wrote an Histoire de Cesar Germanicus, La République romaine, ou plan general de l'ancien gouvernement de Rome. Though not a scholar of the first rank, Beaufort has at least the merit of having been a pioneer in raising the question, afterwards elaborated by Niebuhr, as to the credibility of early Roman history and the importance of source criticism; this article incorporates text from a publication now in the public domain: Chisholm, Hugh, ed.. "Beaufort, Louis de". Encyclopædia Britannica. Cambridge University Press

Dawn Zimmer

Dawn Zimmer is an American politician who served as the 38th mayor of Hoboken, New Jersey. As president of the Hoboken City Council, she became acting mayor after incumbent Peter Cammarano's resignation on July 31, 2009 following his arrest on corruption charges. Zimmer is the first female mayor of Hoboken, she was first elected mayor in a special election for the balance of Cammarano's term on November 6, 2009 and was re-elected mayor for another four-year term in November 2013. In 2012, 2013 and 2014, she was ranked #3, #4 and #5 on The Hudson Reporter's list of the 50 most influential people in Hudson County. Dawn Zimmer was born in Towson and raised in Laconia, New Hampshire, she is of Irish descent. She attended public schools and graduated cum laude in 1990 from the University of New Hampshire with a degree in history. Zimmer taught English at a private language school in Japan from 1990 to 1993, she worked at Sumitomo Corporation of America doing internal and external communications for four years and in public relations specializing in crisis communications at Edelman Worldwide for three years.

She has worked as a family portrait photographer and as marketing director for her husband's jewelry business. She and her family moved to Hoboken from New York City in September 2002. Zimmer became involved in civic life in Hoboken in 2006 when she joined the Southwest Parks Coalition Steering Committee to advocate for more park space in southwest Hoboken's 4th Ward, she served as a board member of the Kaplan Cooperative Preschool and as secretary of the Parent Teacher Student Organization for the Elysian Charter School. In 2007, she ran for Hoboken City Council in the 4th Ward against incumbent Christopher Campos. In the first election in May, neither candidate reached 50 percent. Zimmer outpolled Campos in the June runoff by eight votes, but Campos challenged the results, charging that absentee ballots were improperly handled. Zimmer in turn charged. A second runoff was called in November, with Zimmer defeating Campos by a margin of 1,070 votes to 956. In October 2007, Zimmer, as Hoboken's 4th Ward Councilwoman, supported a voter referendum to create an Open Space Trust Fund.

This fund could have been used to pay maintenance on existing parks but Councilwoman Zimmer and other Councilpeople voted to ensure that it would only be used for the acquisition of new space and the maintenance of new space. Zimmer ran for Mayor of Hoboken in 2009, she lost to Peter Cammarano in the June runoff by 161 votes. On July 1, when Cammarano was sworn in as mayor, the City Council unanimously elected Zimmer as Council President. On July 23, 2009, Cammarano was arrested by the FBI as part of a major corruption and international money laundering conspiracy probe known as Operation Bid Rig. Cammarano was charged with accepting $25,000 in cash bribes from an undercover cooperating witness; the same witness was unsuccessful in setting up a meeting. She joined other local officials in calling for Cammarano's resignation. On July 31, 2009, Cammarano resigned from office, Zimmer was sworn in as acting mayor. On November 3, 2009, she won a special election to fill the rest of Cammarano's mayoral term.

In the special election, Zimmer faced six opponents: City Councilwoman Beth Mason, businessman Frank Raia, former Hoboken Municipal Court judge Kimberly Glatt, Hoboken Republican Club co-founder Nathan Brinkman, management consultant Everton A. Wilson, former corrections officer Patricia Waiters, she finished with 43% of the vote, with Mason in second place with 23% and Raia in third place with 18%. As it was a special election, no runoff was required. Zimmer was sworn in as mayor on November 2009, giving up her City Council seat. In 2008, Hoboken City had come under State Supervision due to an 11.7 million dollar budget deficit. By the end of her first term, Hoboken had a balanced budget, had cut taxes by 12%, the city's bond rating had gone from BBB- to AA+, the second highest S&P rating. Zimmer was re-elected as mayor along with her entire ticket in November 2013. Zimmer played a significant role in privatizing Hoboken University Hospital, keeping it from closing in 2011; the hospital—New Jersey's oldest—faced closure due to severe financial problems.

The City of Hoboken had guaranteed $52 million of the hospital's debt, so its failure would have had been financially devastating for the city. On June 20, 2017, Zimmer announced that she would not seek re-election in the November 2017 municipal election, she explained that she had become concerned about global warming: "With President Trump having pulled our country out of the Paris Accord, demonstrating a lack of commitment to addressing this critical issue at the federal level, I've decided that it is the right time for me to take a new role working more directly on this important issue." In 2012 Zimmer was acclaimed for leadership during the aftermath Hurricane Sandy. On September 9, 2013, she was recognized as "Hero of the Harbor" by the Waterfront Alliance for her work "to make her city a national model for preparedness, meeting with FEMA and state officials, urban planners and many others to create an'integrated solution.'" For her leadership during Hurricane Sandy, Zimmer was appointed to the President's Hurricane Sandy Rebuilding Task Force.

In November 2013, President Obama named Zimmer to the Presidential Task Force on Climate Preparedness and Resilience. In December 2013, Zimmer testified before the U. S. Senate Committee on Small Business & Entrepreneurship on Thursday, December, she discussed the impact Hurricane Sandy has had on Hoboken and the challenges still faced wit

Discovery Land Company

Discovery Land Company is a Scottsdale, Arizona-based developer and operator of private residential communities and clubs in North America and Europe. The company has been called one of the best developers of resort communities by Robb Report Vacation Homes and Luxury Living magazines. In 2010, Discovery Land Company recorded over $600 million in sales. In 2015, the company recorded over $1 billion in sales. Discovery Land Company was founded in 1994 by Michael S. Meldman with the opening of The Estancia Club in Scottsdale and the Iron Horse project in Whitefish, Montana; the company now has 24 properties in Hawaii, Arizona, Idaho, Texas, New York and North Carolina in the U. S. Los Cabos, Rio San Juan, Dominican Republic, West Indies and Great Guana Cay in the Bahamas. In 2019, Discovery opened their first European property in Portugal; the Baker's Bay is a private, property owners only club community perched on the northern 600 acres of Great Guana Cay in the Abaco family islands of the Bahamas, located about 190 miles off the southern coast of Florida.

The community features a golf course designed by Tom Fazio as well as a private, members-only marina. Seventy acres of the club's property is a designated nature preserve, slated to be used for studying nature and eco-recreation; the community is unique in. Chileno Bay Golf & Beach Club is a private community located near Cabo San Lucas on the Sea of Cortez; the club features a golf course designed by Tom Fazio. El Dorado Golf and Beach Club is a private, gated beachfront community and golf club in Los Cabos, Mexico; the club features a golf course designed by former professional golfer Jack Nicklaus. It is a non-equity membership club limited to 395 memberships. Gozzer Ranch is a lakefront community and private club located on 700 acres acres near Coeur d’Alene, Idaho. In 2015, the golf course at Gozzer Ranch was named in Golfweek Magazine's Best Residential Courses; the community includes a private golf course designed by Tom Fazio. There are two marinas; the community has 267 estate-sized homesites, 34 golf cabins, 28 homestead cottages, 28 condominiums.

The Hideaway is a golf club and residential development in California. There are two golf courses at one designed by Clive Clark and one by Pete Dye. Kūkiʻo Golf and Beach Club is a private, residential equity club located adjacent to the Four Seasons Hotel on the Kona-Kohala coast on the Big Island of Hawaii; the club features two golf courses designed by Tom Fazio, one is a 10-hole course, the other is 18 holes. In 2015, Kuki'o was named one of Hawaii's "Best Neighbor Island" resorts by World Property Journal; the Madison Club is a private golf club located adjacent to the Hideaway in California. The golf course was designed by Tom Fazio. Makena is located in the southwest region of Maui and features 36 holes of golf on courses designed by Dennis Wise. Mirabel is a gated golf community that opened in 2001, it covers 713 acres of Sonoran Desert terrain in North Scottsdale, at an elevation of 3,000 feet. It features a golf course designed by Tom Fazio, a 7,147-yard, par-71 course. Mountaintop Golf and Lake Club is a private golf and residential community consisting of 731 acres acres in the Highlands-Cashiers region of the western North Carolina mountains.

The community offers 75 cabins for purchase. Mountaintop is a 2.5 hour drive from Atlanta. The golf course was designed by Tom Fazio and was named one of the best golf communities by Links Magazine; the Silo Ridge Field Club is on 800 acres acres of land in the Hudson Valley in New York. It's adjacent near Millbrook, New York; the Summit Club is nine miles from the Las Vegas Strip and is a private, luxury gated golf community located on 555 acres acres of land within Summerlin. The community will offer a golf course designed by Tom Fazio; the Yellowstone Club is located in Big Sky, Montana and is a 13,600 acres private residential community. The price of residences start at around $4,000,000, members must pay an initial fee of $400,000 to join and $36,000 each year in dues; the community offers 15 chairlifts, three ski lodges, 2,200 acres skiable acres and an 18-hole Tom Weiskopf designed golf course. The golf course was named one of the best golf communities by Links Magazine. In 2008, the Discovery Land Company entered an agreement with Yellowstone Club, establishing a long-term partnership for development and management.

In 2009 the Yellowstone Club was purchased and brought out of bankruptcy by investors led by CrossHarbor Capital Partners, including a 5 percent share by Discovery Land Company. Vaquero is a gated community covering 525 acres in Westlake, Texas near Dallas-Fort Worth and Alliance airports, it features a part-71 golf course designed by Tom Fazio. In 2013, Vaquero was rated by Avid Golfer as the Best Overall Private Country Club. CordeValle Golf Club & Lodge is an invitation-only golf, social and executive retreat for Silicon Valley business leaders and entrepreneurs; the Club’s facilities were developed by Lions Gate Limited Partnership, a Delaware limited partnership. Prior to the issuance of non-equity memberships in the Club, the Lions Gate Limited Partnership transferred its ownership of the Club’s property and the Club Facilities to CordeValle Golf Club, LLC. In March 2007, Cordevalle L. P. a California limited partnership, purchased certain assets from, assumed certain liabilities of, the Initial Developer and CordeValle Golf Club, LLC, including the Club, th

Frank Ramsey (basketball)

Frank Vernon Ramsey Jr. was an American professional basketball player and coach. A 6-5 forward/guard, he played his entire nine-year NBA career with the Boston Celtics and played a major role in the early part of their dynasty, winning seven championships as part of the team. Ramsey was a head coach for the Kentucky Colonels of the ABA during the 1970–1971 season. Ramsey was inducted into the Naismith Basketball Hall of Fame in 1982. Raised in Madisonville, Ramsey was a multi-sport athlete at the University of Kentucky, playing baseball as well as basketball. Playing under legendary coach Adolph Rupp, Ramsey, as a sophomore in 1951, helped the Wildcats win the NCAA Championship with a 68-58 victory over Kansas State. In the fall of 1952, a point shaving scandal involving three Kentucky players over a four-year period forced Kentucky to forfeit its upcoming season, Ramsey's senior year, as well as that of Cliff Hagan and Lou Tsioropoulos; the suspension of the season made Kentucky's basketball team, in effect, the first college sports team to get the "death penalty", although it was nothing more than the NCAA asking members schools not to schedule Kentucky, not mandating it.

Ramsey and Tsioropoulos all graduated from Kentucky in 1953 and, as a result, became eligible for the NBA draft. All three players were selected by the Boston Celtics—Ramsey in the first round, Hagan in the third, Tsioropoulos in the seventh. All three returned to Kentucky for one more season despite graduating. After finishing the regular season with a perfect 25-0 record and a #1 ranking in the Associated Press, Kentucky had been offered a bid into the NCAA Tournament. However, then-existing NCAA rules prohibited graduate students from participating in post-season play. Ramsey played on Kentucky Wildcats baseball team, earning All-SEC honors as an outfielder in 1951, 1952 and 1954. Upon completion of his college basketball career, Ramsey scored 1344 points, which at the time ranked him fourth in the school's history, grabbed 1038 rebounds, a school record surpassed by one of his future Kentucky Colonels players, Dan Issel. After playing his rookie season with the Celtics, Ramsey spent one year in the military before rejoining the team.

In the eight seasons he played after military service, he was a member of seven championship teams. He was a major contributor of the Celtics dynasty, playing behind the duo of Bob Cousy and Bill Sharman and playing with Bill Russell, Sam Jones, K. C. Jones, Tom Heinsohn, John Havlicek and Satch Sanders. In his 623 NBA games Ramsey scored 8378 points for an average of 13.4 points per game. He was inducted into the Naismith Memorial Basketball Hall of Fame in 1981, his #23 is retired by the Celtics. Ramsey's best statistical season was 1957–1958, it was his only post-military season in which the Celtics did not win the NBA championship. Ramsey was a head coach for one season in the ABA with the Kentucky Colonels, who were led by two former Kentucky Wildcats – Issel, a rookie, Louie Dampier. Ramsey was named coach 17 games into an 84-game season and, though he had a 32-35 record, coached the Colonels into the playoffs; the Colonels lost to the Utah Stars in the 1971 ABA Finals, 4 games to 3. Joe Mullaney replaced Ramsey as coach the following season.

Prior to coaching in the ABA, Ramsey had been Red Auerbach's first choice to replace his mentor as Celtics coach after Auerbach retired at the end of the 1965–66 season. However, Ramsey decided to move back to Madisonville. Auerbach is credited throughout basketball with creating the sixth man. Though Ramsey was one of the Celtics' best players, he felt more comfortable coming off the bench and Auerbach wanted him fresh and in the lineup at the end of close games. Ramsey was the first in a series of sixth men. In the championships the Celtics won after Ramsey's retirement, they have had successful sixth men such as Havlicek, Paul Silas, Kevin McHale, Bill Walton, James Posey. Ramsey was mentioned in the episode ``. Bud asked Al the trivia question, "Who was known as the best sixth man in basketball? He played for the Celtics", to which Al nonchalantly replied, "Frank Ramsey". However, little did. On November 15, 2005, Ramsey's house was destroyed in a tornado that hit his residence in Madisonville.

One of his plaques was found miles away from his home, Ramsey himself was found unhurt. As of June 2008, Ramsey was a bank president in Kentucky. Ramsey died of natural causes in his hometown of Madisonville, Kentucky on July 8, 2018 at the age of 86. Ramsey was inducted into the Naismith Basketball Hall of Fame in 1982. In 2005, Ramsey was inducted into the University of Kentucky Athletics Hall of Fame. In 2006, Ramsey was a charter inductee to the College Basketball Hall of Fame. Ramsey's #2

LSU Tigers softball

The LSU Tigers softball team represents Louisiana State University in NCAA Division I college softball. The team plays home games in Tiger Park; the team is coached by Beth Torina. LSU has won nine Western Division titles, five regular season SEC championships and five SEC tournament championships. LSU has appeared in six Women's College World Series and nineteen NCAA tournaments; the team has finished fifth two times. LSU softball had its beginnings in 1979 with a team coached by Carol Smith. However, after only three seasons, LSU decided to disband its softball program. During Smith's tenure, she coached the team to an overall record of 45–28. In 1997 the Southeastern Conference decided to begin sponsoring softball to help member institutions to comply with Title IX. LSU softball was reborn with the hiring of Cathy Compton from Nicholls State University. Compton was head coach from 1997 through the 1998 regular season and finished with an overall record of 100–26 and 41–12 in the SEC. Glenn Moore became head coach at LSU starting with the 1998 NCAA Tournament.

He was head coach at LSU through the 2000 season and compiled a 117–25 overall record and 53–7 SEC record. In 2001, LSU hired NFCA Hall of Fame head coach Yvette Girouard from the University of Louisiana at Lafayette. During her 11 years as head coach, Girouard had an overall record of 526–171–1 and SEC record of 220–93–1, she led the Tigers to two College Women's World Series appearances and made the NCAA Tournament in ten of her eleven years as head coach. She coached LSU to three SEC championships and four SEC tournament championships, she retired following the 2011 season. During Girouard's tenure as head coach, LSU moved into the new Tiger Park during the spring of 2009 after playing at the Original Tiger Park that opened in 1997. On June 9, 2011, LSU announced long-time Alabama head coach Patrick Murphy was hired to replace Yvette Girouard. However, three days Murphy announced that he had changed his mind and would remain at Alabama. LSU hired Beth Torina, head coach at Florida International University on June 20, 2011.

Torina led the Tigers to the College Women's World Series in her first season as head coach in 2012 and has led the Tigers to the World Series in 2015, 2016 and 2017. With Torina as head coach, the program earned its 1,000th victory on May 1, 2016 after defeating the Arkansas Razorbacks 9-1 in Fayetteville, Arkansas. Tiger Park serves as the home field of the LSU Tigers softball team; the official capacity of the stadium is 1,289 people. The stadium features an outfield berm, renamed the Tiger Park Terrace in 2016, that can accommodate an additional 1,200 fans; the original Tiger Park was a softball stadium located on the campus of Louisiana State University in Baton Rouge, Louisiana. It served as the home field of the LSU Tigers softball team from 1997-2008; the official capacity of the stadium was 1,000 people. The stadium was opened prior to the 1997 college softball season and played host to four NCAA Regionals in 1999, 2000, 2001, 2006 and hosted the 2008 SEC Softball Tournament; the 2008 season was the final season in the original Tiger Park.

LSU closed out the original Tiger Park with a home record of 331-51, including 140-34 in the SEC and 1-1 in the SEC Tournament. The LSU North Stadium Weight Room strength training and conditioning facility is located in the LSU Strength and Conditioning facility. Built in 1997, it is located adjacent to Tiger Stadium. Measuring 10,000-square feet with a flat surface, it has 28 multi-purpose power stations, 36 assorted selectorized machines and 10 dumbbell stations along with a plyometric specific area, medicine balls, plyometric boxes and assorted speed and agility equipment, it features 4 treadmills, 6 stationary bikes, 4 elliptical cross trainers, 2 stair stepper and stepmill. LSU Tigers and Lady Tigers List of NCAA Division I softball programs Official website