The discovery of the neutron and its properties was central to the extraordinary developments in atomic physics in the first half of the 20th century. Early in the century, Ernest Rutherford developed a crude model of the atom, based on the gold foil experiment of Hans Geiger and Ernest Marsden. In this model, atoms had their mass and positive electric charge concentrated in a very small nucleus. By 1920, isotopes of chemical elements had been discovered, the atomic masses had been determined to be (approximately) integer multiples of the mass of the hydrogen atom, and the atomic number had been identified as the charge on the nucleus. Throughout the 1920s, the nucleus was viewed as composed of combinations of protons and electrons, the two elementary particles known at the time, but that model presented several experimental and theoretical contradictions.

The atomic number or nuclear charge number of a chemical element is the charge number of an atomic nucleus. For ordinary nuclei composed of protons and neutrons, this is equal to the proton number (np) or the number of protons found in the nucleus of every atom of that element. The atomic number can be used to uniquely identify ordinary chemical elements. In an ordinary uncharged atom, the atomic number is also equal to the number of electrons.