Dmanisi is a town and archaeological site in the Kvemo Kartli region of Georgia approximately 93 km southwest of the nation’s capital Tbilisi in the river valley of Mashavera. The hominin site is dated to 1.8 million years ago. It was the earliest known evidence of hominins outside Africa before stone tools dated to 2.1 million years were discovered in 2018 in Shangchen, China.

Kvemo Kartli or "Lower Kartli", is a historic province and current administrative region (mkhare) in southeastern Georgia. The city of Rustavi is the regional capital.