Domenico Zampieri, known by the diminutive Domenichino after his shortness, was an Italian Baroque painter of the Bolognese School of painters.

The Bolognese School of painting, also known as the School of Bologna, flourished between the 16th and 17th centuries in Bologna, which rivalled Florence and Rome as the center of painting in Italy. Its most important representatives include the Carracci family, including Ludovico Carracci and his two cousins, the brothers Agostino and Annibale Carracci. Later, it included other Baroque painters: Domenichino and Lanfranco, active mostly in Rome, eventually Guercino and Guido Reni, and Accademia degli Incamminati in Bologna, which was run by Lodovico Carracci. Certain artistic conventions, which over time became traditionalist, had been developed in Rome during the first decades of the 16th century. As time passed, some artists sought new approaches to their work that no longer reflected only the Roman manner. The Carracci studio sought innovation or invention, seeking new ways to break away from traditional modes of painting while continuing to look for inspiration from their literary contemporaries; the studio formulated a style that was distinguished from the recognized manners of art in their time. This style was seen as both systematic and imitative, borrowing particular motifs from the past Roman schools of art and innovating a modernistic approach.