Domenico Gattilusio was the fifth Gattilusio lord of Lesbos from 1455 to 1458. He was a son of Dorino I Gattilusio and Orietta Doria.
Bronze denaro of Domenico Gattilusio, with a large "D" on the obverse, and the tetragrammatic cross of the Byzantine Empire on the reverse
Relief at the Castle of Mytilene, showing the eagle of the Doria family (far left), the family cypher of the Palaiologoi (center left), and the Gattilusi coat of arms (center right)