Domenico Grimani was an Italian nobleman, theologian and cardinal. Like most noble churchmen of his era, Grimani was an ecclesiastical pluralist, holding numerous posts and benefices.

The House of Loredan-Santo Stefano was a cadet branch of the House of Loredan that existed from the 14th century until 1767. The branch was mainly settled in the Palazzo Loredan in Campo Santo Stefano