Domenico "Domingo" Ghirardelli was an Italian-born chocolatier who was the founder of the Ghirardelli Chocolate Company in San Francisco, California.

The Ghirardelli Chocolate Company is an American confectioner, wholly owned by Swiss confectioner Lindt & Sprüngli. The company was founded by and is named after Italian chocolatier Domenico Ghirardelli, who, after working in South America, moved to California. The Ghirardelli Chocolate Company was incorporated in 1852, and is the third-oldest chocolate company in the US, after Baker's Chocolate and Whitman's.