The Dominion Building is a commercial building in Vancouver, British Columbia, Canada. Located on the edge of Gastown, it was Vancouver's first steel-framed high-rise. At 53 m (175 ft), the thirteen-storey, Second Empire style building was the tallest commercial building in the British Empire upon its completion in 1910. Its architect was John S. Helyer, who is said to have died after falling off the staircase in the front of the building, though this is an urban legend.

Gastown is the original settlement that became the core of the city of Vancouver, British Columbia, Canada, and a national historic site and a neighbourhood in the northwest section of the Downtown Eastside, adjacent to Downtown Vancouver.