Don't Give Up on Me is a studio album by American R&B/Soul singer Solomon Burke, recorded and released in 2002 on Fat Possum Records. The album won the Grammy Award for Best Contemporary Blues Album. It is noteworthy for the contributions of original and previously unreleased compositions by top-rank songwriters, the effect of which placed Burke back in the public eye for a time. Guest stars are Daniel Lanois, who plays electric guitar on "Stepchild", and The Blind Boys of Alabama, who feature on backing vocals for "None of Us Are Free". "None of Us Are Free" was also featured at the end of the sixth episode ("Spin") of the second season of House. "Fast Train" was featured during the ending montage of the season three finale of The Wire.

Solomon Vincent McDonald Burke was an American singer who shaped the sound of rhythm and blues as one of the founding fathers of soul music in the 1960s. He has been called "a key transitional figure bridging R&B and soul", and was known for his "prodigious output".