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Melorheostosis is a medical developmental disorder and mesenchymal dysplasia in which the bony cortex widens and becomes hyperdense in a sclerotomal distribution. The condition is characterized by thickening of the bones. Pain is a frequent symptom and the bone can have the appearance of dripping candle wax. A randomly occurring somatic mutation of the MAP2K1 gene during fetal development is believed to be the cause, it is not known if LEMD3 mutations can cause isolated melorheostosis in the absence of osteopoikilosis or Buschke–Ollendorff syndrome. Melorheostosis is a mesenchymal dysplasia manifesting as regions of dripping wax appearance or flowing candle wax appearance; the disorder can be detected by radiograph due to thickening of bony cortex resembling "dripping candle wax." It is included on the spectrum of developmental bone dysplasias including pycnodysostosis and osteopoikilosis. The disorder tends to be unilateral and monostotic, with only one limb involved. Cases with involvement of multiple limbs and bones in the spine have been reported.

There are no reported cases of involvement of skull or facial bones. Melorheostosis can be associated with pain, physical deformity and circulation problems and functional limitation, it is associated with a benign inner ear dysplasia known as osteosclerosis. The disorder is progressive, with the ultimate severity of symptoms depending on age of onset. In severe cases amputation has been performed when conservative measures such as physical therapy and regional anesthetics have been ineffective. List of radiographic findings associated with cutaneous conditions 01061 at CHORUS

Alabama Policy Institute

The Alabama Policy Institute is a nonprofit, conservative think tank located in Alabama. According to the organization's mission statement, it is "dedicated to influencing public policy in the interest of the preservation of free markets, limited government and strong families." API is headquartered in Alabama. The Alabama Policy Institute was founded in 1989 as the Alabama Family Alliance. Alabama Supreme Court justice Tom Parker was the founding executive director. Gary Palmer, a co-founder of the Alabama Family Alliance became its president. In 2000, the Alabama Family Alliance was renamed the Alabama Policy Institute. After 25 years at the helm, Palmer stepped down from his role as the institute's president in order to make a 2014 run for Alabama's 6th congressional district, he was replaced by Caleb Crosby, who had served as API's vice president and CFO prior to becoming the group's president in September 2014. In September 2019 it was announced that Alabama Governor Kay Ivey's former communications director Josh Pendergrass had been named API's chief communications officer.

API researches policy issues and offers analysis and proposals through reports and publications to public servants and the media. As a conservative think tank, API addresses a range of policy issues in the areas of economics, the environment, government and society. API has argued for. In 2003, API was a staunch opponent of Republican Governor Bob Riley's $1.2 billion tax increase proposal. It commissioned a study by the Beacon Hill Institute about Riley's tax increase legislation. API has been a critic of proposals for an Alabama state lottery, labeling such proposals a regressive tax on the poor. API has championed charter schools in Alabama, it supports the Alabama Accountability Act, which expanded school choice and school vouchers in the state. API was a proponent of both the Marriage Act, passed in 1998, Alabama Amendment 774, approved by 81% of Alabama voters in 2006. In 2014, API released, it covered energy, air quality, water quality and land, toxic release inventory and climate change.

It provided a positive outlook on the state of the environment, arguing that the nation's air quality and the environment in general are improving. In February 2015, the Alabama Policy Institute and the Alabama Citizens Action Program filed a lawsuit asking the Alabama Supreme Court to halt same-sex marriages in the state until the United States Supreme Court addresses the issue. Official website Organizational Profile – National Center for Charitable Statistics

Epic Mickey 2: The Power of Two

Epic Mickey 2: The Power of Two is a platform video game published by Disney Interactive Studios, is the sequel to Epic Mickey. The game was first released on the PlayStation 3, Wii U, Xbox 360 in November 2012, would make further releases on the PlayStation Vita, Microsoft Windows over the next two years; the game features an optional co-op mode where a second player could play as Oswald and help Mickey save the magical world of Wasteland. The game has a companion called Epic Mickey: Power of Illusion for the Nintendo 3DS. All has been well in Wasteland since Mickey helped defeat the Shadow Blot, with all the forgotten characters rebuilding their home. However, a series of earthquakes threatens to undo the world; the Mad Doctor at the asks Oswald to join forces with him to help repair Wasteland. Not trusting the Mad Doctor, the leader of the Gremlins, Ortensia, Oswald's wife, contact Mickey Mouse. Mickey once more enters Yen Sid's workshop and takes the magic brush to aid him as he enters Wasteland.

Oswald joins up with them in Dark Beauty Castle, explaining the Mad Doctor warned him of the Blotworx - Blotlings piloting mechanical suits - which have taken control of the Beetleworx production. The castle begins forcing them to escape. Mickey and Oswald arrive in Mean Street, where Gremlin Jamface advises them to fix the disabled Projectors via their control station in Rainbow Falls, they fight their way through Wasteland, defeating Blotlings and Blotworx. After heading to the Mad Doctor's lab in Disney Gulch and defeating a giant robotic dragon, they find out the projectors were intentionally sabotaged, notice one of the Gremlins named Prescott is acting strangely and follow him; this takes them to Fort Wasteland, an area, seemly destroyed before the events of Mickey's last visit, help a ghost named Ian befriend the local Blotlings, whom he believes are just misunderstood. They are lead to the Floatyard, where they find Prescott has built a massive robot designed after him, which he sends to attack the group.

Destroying or trapping the mech and Oswald try interrogating Prescott, only to have Animatronic Daisy Duck's news team and the Mad Doctor arrive. The Mad Doctor announces a new mystery attraction he will be building in Wasteland. Concerned and Oswald follow the Mad Doctor's trail through Ventureland to his hideout, which leads them through Autotopia, another area, supposedly destroyed during the Blot's revolt. While traveling through a projector leading to Lonesome Manor's attic, they learn what happened after he was sent flying away during Mickey's previous visit: he crash-landed in Disney Gulch and set up a lab there, it is revealed that he was the one who created the Blotworx, made from captured Blotlings and cars from Autotopia, but was forced to cast them out because of their hostile nature. After saving Jamface from Beetleworx, they find the Mad Doctors diary, from which they learn that he convinced Prescott to build him a TV to broadcast a show called The Mad Doctor's World of Evil into the Cartoon world so people can remember him and give him the heart to escape Wasteland and that he wishes to become a Toon again using creatures of paint and thinner called Guardians.

He was the cause of the earthquakes via Guardian extraction devices found in Autotopia. They confront the Mad Doctor at his "mystery attraction", where he demands the magic brush from Mickey in exchange for their friends whom he has kidnapped, but Oswald prevents this from happening as it will make the Mad Doctor unstoppable, they defeat the Mad Doctor, whose robotic body gives out and is either defeated or redeemed depending on which path was taken in his fight. Afterward, the Wasteland celebrates Mickey and Oswald's triumph with a parade highlighting the duo's major choices in the game. However, the Petes of Wasteland, with Petetronic being present if Mickey and Oswald achieve the bad ending, kidnap Prescott having plans for both him and Wasteland. Like its predecessor, Epic Mickey 2 takes place in a world based on classic and retired Disney characters and attractions; the gameplay in Epic Mickey 2 resembles that of the original. One of the biggest updates is the addition of Oswald as a supporting character for Mickey.

Oswald uses a remote control in a way similar to how Mickey uses his paintbrush, to attack or befriend enemy characters and to alter the environment as needed to complete tasks. Oswald has many other abilities, such as flying with his ears, taking off his leg, using his arms as boomerangs, etc. There are some special abilities that can only be used when Mickey and Oswald are working together. In the PlayStation 3 version of the game, players are able to use motion controls using the PlayStation Move controller. On August 27, 2011, Destructoid posted an article that speculated that a sequel, Epic Mickey 2, was in development and showed possible box art for the game; these rumors were further encouraged when Disney France and Warren Spector invited the French media to an "epic project" taking place on March 27, 2012. Nintendo Power magazine commented on the rumor, stating that their April 2012 issue would include a "top-secret" title preview, with the preview for the issue showing a cropped down picture of Oswald the Lucky Rabbit.

Game Trailers stated that their March 22, 2012 episode would include

Ehsan Hoque

Ehsan Hoque is a medical doctor, social entrepreneur and child rights activist. He is the founder and honorary Executive Director of Distressed Children & Infants International, an international non-profit organization based in the United States that works with underprivileged children and their families to stop child labor, extend educational opportunities, provide access to healthcare. Hoque was born in Barisal, Bangladesh to A. N. Shamsul Hoque and Hasina Begum, in 1964, he was born with congenital cataracts, by the age of five had undergone seven eye surgeries, which restored his vision. At the time cataract surgery was uncommon in Bangladesh. Despite his family and physician advising him against prolonged studying and suggested he not attend school due to his impaired vision, he persevered in his studies and by 1987 he had graduated from Rajshahi Medical College to become a medical doctor, he completed his Ph. D. in 1995 at Asahikawa Medical College and his postdoctoral fellowship in 1997 at the University of Western Ontario.

Over the course of his career, Hoque has worked at numerous institutes around the world, including Rajshahi Medical College Hospital, Dhaka Shishu Hospital, Asahikawa Medical University, University of Western Ontario, University of Toronto, Yale University School of Medicine. His research has focused on cardiovascular pharmacology and physiology, concentrating on ischemic reperfusion injury of the heart, neuroendocrinology with a focus on aging. Hoque has published his work in various scientific journals, presented his findings at national and international conferences, he has been the recipient of numerous academic honors, including a Monbusho Scholarship from the Japanese Ministry of Education, research awards from the Heart & Stroke Foundation of Ontario, the University of Toronto Research Fellowship, the Hartford Foundation Fellowship. Hoque is now a dedicated activist for children's rights and serves as full-time Executive Director of the American non-profit organization Distressed Children & Infants International.

He is involved with eye research projects at Yale University with colleague Brian DeBroff and serves as Honorary Goodwill Ambassador and International Consultant for Thengamara Mohila Sabuj Sangha, one of the largest non-governmental organizations in Bangladesh. Hoque advocates for those with disabilities and promote inclusion efforts to normalize their lives. In 1995 Ehsan Hoque discovered that Lysophosphatidylcholine, a toxic substance which accumulates in the ischemic myocardium when applied exogenously, causes ischemia-like changes, suggesting that LPC is one of the important factors in producing ischemia-reperfusion derangements in terms of mechanical and metabolic functions, he found that prevention of LPC accumulation can protect heart from ischemia/reperfusion injury. In 1997 Ehsan Hoque was the first to demonstrate the potential protective effect of NHE inhibition on Lysophosphatidylcholine -induced cardiac injury; as a young boy, Hoque was bullied for wearing heavy eyeglasses and taking longer to do things due to poor vision.

He cites this as a major source of his empathy for others who are disadvantaged through no fault of their own. Living in Bangladesh, he was surrounded by people in poverty and developed a deep appreciation for his own life. In his words, "I feel so lucky that I had parents who could give me food, clean water, a bed to sleep in and treatment so I could see. If I was born into a poor family I would not be able to see the world today." At a young age he involved himself in charitable activities with several organizations. During high school he created a volunteer group and started to help underprivileged people during natural disasters common to the country like cyclones and floods; as a young physician, Hoque undertook his own voluntary projects in remote villages teaching women about prenatal nutrition and distributing vegetable seeds and vitamin tablets to prevent the vitamin deficiency that contributed to his own partial blindness. During these trips he saw small children dropping out of school and being sent to work in factories or as maids to support their families.

He saw many of these children abused and tortured by their employers. In 1995, Hoque started supporting the education of 50 children to save them from child labor, in the process realized a more systematic approach was necessary to help the many more children suffering the same fate in Bangladesh and elsewhere; this inspired him to form a non-governmental organization to prevent school dropouts on a large scale by providing comprehensive support through child sponsorship, creating a safety net and involving school authorities and the community in the process. This dream was realized in 2003 when, together with his colleague at Yale University Brian DeBroff and his wife Nina Hoque, he founded Distressed Children & Infants International, or DCI; the organization's mission is to reduce the extreme poverty that contributes to child labor by providing quality education, family support, access to healthcare with a focus on eliminating preventable blindness. Hoque's vision of child sponsorship has manifested itself in DCI's Sun Child Sponsorship Program, which now supports over 1500 children in Bangladesh.

DCI operates several other programs in Bangladesh that provide healthcare, vision care, orphan support, provides support to partner organizations with similar missions in India and Nicaragua. These efforts have benefited thousands of children and their families while providing opportun

Chattakkari (2012 film)

Chattakaari is a 2012 Malayalam romantic drama film written by Thoppil Bhasi based on Pamman's famous novel of the same name and directed by Santosh Sethumadhavan. It is the remake of the 1974 film of the same name, directed by K. S. Sethumadhavan, the father of Santhosh; the film was produced by Suresh Kumar under the banner of Revathy Kalamandir. It stars Shamna Kasim in the title roles. Julie is the eldest daughter of an Anglo-Indian engine-driver. Usha her close friend is from an orthodox Hindu Warrier family. At Usha's residence she meets her brother Sasi, studying at a different place. Julie soon falls in love with Sasi; the relationship gets more cozy and Julie gets pregnant. The rest of the plot revolves around the struggles of Julie and her baby boy, against the hypocratic fangs of society; the plot addresses themes like Life of Anglo-Indians in Kerala, the alarming rise in Premarital Pregnancy and the taboo associated with Inter caste Love and Marriage, all of which were hot topics of discussion when the movie released in 1974.

According to the producer Suresh Kumar, the relevance of the remake lies in the present day Kerala society, still no different from the society, with respect to these social Being a heroine oriented film, the role of Julie was first to be fixed. Many mainstream Malayalam Actresses were considered, the team zeroed in on Shamna. Hemanth Menon, who has acted in some Malayalam movies was fixed as the male lead. Innocent plays the character of Morris, handled by the thespian of Malayalam Cinema, Adoor Bhasi. Sukumari is the only actress present in both the versions of the movie; the support cast include Suvarna and Malu Raveendranath, portraying the characters of Julie's mother and Sister respectively. The film was shot predominantly at Ooty, with some scenes being shot at Udhagamandalam railway station, hill stations in Trivandrum; the filming completed in a record 25 days. A song was shot near Thodupuzha amidst heavy rain; the film features a soundtrack composed by M. Jayachandran with lyrics penned by Murukan Kattakada, Rajeev Alunkal, Charu Hariharan.

The music for the film was released on 2 June 2012 by Honorable Minister for Film Development K. B. Ganesh Kumar at Kanakakkunnu Palace; the behind the scenes videos of the songs "Nilave Nilave" and "Oh My Julie" were released online in YouTube. ‘Chattakkari’ is a hit! Chattakkari on IMDb