The Donner und Blitzen River is a river on the eastern Oregon high desert that drains a relatively arid basin, the southern portion of Harney Basin, from roughly 20 to 80 miles south-southeast of Burns including Malheur National Wildlife Refuge. Though much of its course is marsh, it offers scenic glaciated canyons, unique ecosystems, and exceptional wild trout fisheries. Named by soldiers of German origin, the Donner und Blitzen River translates as "thunder and lightning". The name usually brings to mind two of Santa Claus's reindeer, but the river is named for a thunderstorm the soldiers experienced as they crossed the river; dry lightning is an almost daily occurrence in the region during certain times of the year.

The Harney Basin is an endorheic basin in southeastern Oregon in the United States at the northwestern corner of the Great Basin. One of the least populated areas of the contiguous United States, it is located largely in northern Harney County, bounded on the north and east by the Columbia Plateau—within which it is contained, physiographically speaking—and on the south and west by a volcanic plain. The basin encompasses an area of 1,490 square miles (3,859 km2) in the watershed of Malheur Lake and Harney Lake. Malheur Lake is a freshwater lake, while Harney Lake is saline-alkaline.