"Down 4 U" is the lead single from Murder Inc. Records' compilation album Irv Gotti Presents: The Inc., released through Def Jam Recordings and Irv Gotti's Murder Inc. Records. The song features rapped verses from Ja Rule, Charli Baltimore, and Vita while Ashanti provides the chorus and sung vocals. The song is a remix as well as its music video being the sequel of Ja Rule's 2002 single, "Down Ass Bitch".

Murder Inc. Records, LLC, also abbreviated as The Inc. Records, is an American record label founded by brothers Chris and Irv Gotti in 1998. The label's flagship artist was Ja Rule. According to Chris Gotti, Murder Inc. had sold over 30 million units worldwide and grossed over $500 million. Murder Inc. was headquartered at One Worldwide Plaza in Midtown Manhattan, New York City, New York, while their main studio was The Crackhouse, also located in New York City.