Down to the Bone is a 2004 American independent drama film, directed by Debra Granik and written by Granik and Richard Lieske. It stars Vera Farmiga, who received a Best Actress Award from the Los Angeles Film Critics Association for her role as the drug addicted Irene. The film premiered at the Sundance Film Festival on January 15, 2004, where it won the Director's Award (Granik) and the Special Jury Prize for Acting (Farmiga). The film received a limited release in the United States on November 25, 2005.

Debra Granik is an American filmmaker. She is most known for 2004's Down to the Bone, which starred Vera Farmiga, 2010's Winter's Bone, which starred Jennifer Lawrence in her breakout performance and for which Granik was nominated for the Academy Award for Best Adapted Screenplay, and 2018's Leave No Trace, a film based on the book My Abandonment by Peter Rock.