Downingtown High School is an American secondary school located in Downingtown, Pennsylvania and Uwchlan Township, Pennsylvania. Population growth in the burgeoning Downingtown Area School District forced the original Downingtown High School to split into two campuses: Downingtown High School East Campus and Downingtown High School West Campus. While still legally considered one school, the two campuses are generally regarded as separate entities.

Downingtown is a borough in Chester County, Pennsylvania, United States, 33 miles (53 km) west of Philadelphia. As of the 2020 census, it had a population of 7,898. Downingtown was settled by European colonists in 1716 and has a number of historic buildings and structures.