Downtown Portland is the central business district of Portland, Oregon, United States. It is on the west bank of the Willamette River in the northeastern corner of the southwest section of the city and where most of the city's high-rise buildings are found.

Portland is a port city in the Pacific Northwest and the most populous city in the U.S. state of Oregon. Situated in the northwestern area of the state at the confluence of the Willamette and Columbia rivers, it is the county seat of Multnomah County, Oregon's most populous county. As of 2020, Portland's population was 652,503, making it the 26th-most populous city in the United States, the sixth-most populous on the West Coast, and the second-most populous in the Pacific Northwest, after Seattle. Approximately 2.5 million people live in the Portland–Vancouver–Hillsboro, OR–WA metropolitan statistical area, making it the 25th most populous in the United States. About half of Oregon's population resides within the Portland metropolitan area.