Downtown San Antonio is the central business district of San Antonio, Texas and the urban core of Greater San Antonio, a metropolitan area with nearly 2.5 million people.

Interstate 10 (I-10) is the major east–west Interstate Highway in the Southern United States. In the U.S. state of Texas, it runs east from Anthony, at the border with New Mexico, through El Paso, San Antonio, and Houston to the border with Louisiana in Orange. At just under 880 mi (1,420 km), the Texas segment of I-10, maintained by the Texas Department of Transportation, is the longest continuous untolled freeway in North America that is operated by a single authority. It is also the longest stretch of Interstate Highway with a single designation within a single state. Mile marker 880 and its corresponding exit number in Orange, Texas, are the highest-numbered mile marker and exit on any freeway in North America. Since widening was completed in 2008, a portion of the highway west of Houston is now also believed to be the widest in the world, at 26 lanes when including feeders.