Downtown St. Louis is the central business district of St. Louis, Missouri, the hub of tourism and entertainment, and the anchor of the St. Louis metropolitan area. The downtown is bounded by Cole Street to the north, the river front to the east, Chouteau Avenue to the south, and Tucker Boulevard to the west. The downtown is the site of many corporate headquarters, including Stifel Financial Corp., HOK, Spire Inc, and a host of other companies.

St. Louis is an independent city in the U.S. state of Missouri. It is located near the confluence of the Mississippi and the Missouri rivers. In 2020, the city proper had a population of 301,578, while its bi-state metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million. It is the largest metropolitan area in Missouri and the second largest in Illinois. The city's combined statistical area (CSA) is the 20th largest in the United States.