Dr. Mario 64 is a tile-matching action puzzle video game developed and published by Nintendo for the Nintendo 64. The game was released in North America on April 9, 2001. The game is an enhanced remake of Dr. Mario, which was originally released for the NES and Game Boy consoles in 1990, and is based around characters from the 2000 Game Boy Color game Wario Land 3. The game's soundtrack was composed by Seiichi Tokunaga, featuring arrangements of classic Dr. Mario tunes and new compositions.

The Nintendo 64 (N64) is a home video game console developed and marketed by Nintendo. It was released in Japan on June 23, 1996, in North America on September 29, 1996, and in Europe and Australia on March 1, 1997. The successor to the Super Nintendo Entertainment System, it was the last major home console to use cartridges as its primary storage format until the Nintendo Switch in 2017. As a fifth-generation console, the Nintendo 64 primarily competed with the Sony PlayStation and the Sega Saturn.