Drakes Estero is an expansive estuary in the Point Reyes National Seashore of Marin County on the Pacific coast of northern California in the United States, approximately 25 miles (40 km) northwest of San Francisco.

Point Reyes National Seashore is a 71,028-acre (287.44 km2) park preserve located on the Point Reyes Peninsula in Marin County, California. As a national seashore, it is maintained by the US National Park Service as an important nature preserve. Some existing agricultural uses are allowed to continue within the park. Clem Miller, a US Congressman from Marin County, wrote and introduced the bill for the establishment of Point Reyes National Seashore in 1962 to protect the peninsula from development which was proposed at the time for the slopes above Drake's Bay.