Drug barons of Colombia refer to some of the most notable drug lords which operate in illegal drug trafficking in Colombia. Several of them, notably Pablo Escobar, were long considered among the world's most dangerous and most wanted men by U.S. intelligence. "Ruthless and immensely powerful", several political leaders, such as President Virgilio Barco Vargas, became convinced that the drug lords were becoming so powerful that they could oust the formal government and run the country.

The illegal drug trade in Colombia has, since the 1970s, centered successively on four major drug trafficking cartels: Medellín, Cali, Norte del Valle, and North Coast, as well as several bandas criminales, or BACRIMs. The trade eventually created a new social class and influenced several aspects of Colombian culture, economics, and politics.