Drusilla, or Dru for short, is a fictional character on the television series Buffy the Vampire Slayer and Angel, portrayed by Juliet Landau. Created by Joss Whedon and David Greenwalt, she is introduced as a main antagonist alongside her lover Spike in the second season of Buffy. In addition to returning in subsequent seasons, the character is featured as a villain on the spin-off show Angel as well. Flashbacks in both series reveal Drusilla's past as a young psychic in Victorian London who was driven insane by Angel before he ultimately turned her into a vampire. Spike and Dru are notably more subversive compared to other "Big Bads" that have opposed Buffy Summers. The duo was conceived as a Sid and Nancy-inspired vampiric pair so Landau chose to portray Drusilla with a Cockney accent, while the character's physical appearance drew from sources such as supermodel Kate Moss and the 1990s heroin chic aesthetic.

The fifth season of the television series Buffy the Vampire Slayer premiered on September 26, 2000, on The WB and concluded its 22-episode season on May 22, 2001. It maintained its previous timeslot, airing Tuesdays at 8:00 pm ET. This was the final season to air on The WB before it moved to UPN; The WB billed the season five finale as "The WB series finale".