Drusilla, or Dru for short, is a fictional character on the television series Buffy the Vampire Slayer and Angel, portrayed by Juliet Landau. Created by Joss Whedon and David Greenwalt, she is introduced as a main antagonist alongside her lover Spike in the second season of Buffy. In addition to returning in subsequent seasons, the character is featured as a villain on the spin-off show Angel as well. Flashbacks in both series reveal Drusilla's past as a young psychic in Victorian London who was driven insane by Angel before he ultimately turned her into a vampire. Spike and Dru are notably more subversive compared to other "Big Bads" that have opposed Buffy Summers. The duo was conceived as a Sid and Nancy-inspired vampiric pair so Landau chose to portray Drusilla with a Cockney accent, while the character's physical appearance drew from sources such as supermodel Kate Moss and the 1990s heroin chic aesthetic.

Buffy the Vampire Slayer is an American supernatural drama television series created by writer and director Joss Whedon. The concept is based on the 1992 film, also written by Whedon, although they are separate and unrelated productions. Whedon served as executive producer and showrunner of the series under his production tag Mutant Enemy Productions. It premiered on March 10, 1997, on The WB and concluded on May 20, 2003, on UPN.