Du Quoin is a city in Perry County, Illinois. It is best known for hosting the annual DuQuoin State Fair and the Street Machine Nationals. The population is estimated at 5,761 in the 2020 census.

Perry County is in Illinois. According to the 2020 census, it had a population of 20,945. Its county seat is Pinckneyville. It is located in the southern portion of Illinois known as "Little Egypt".