The Ducati Panigale V4 is a sport bike with a 1,103 cc (67.3 cu in) desmodromic 90° V4 engine introduced by Ducati in 2018 as the successor to the V-twin engined 1299. A smaller engine displacement version complies with the Superbike category competition regulations which state "Over 750 cc up to 1000 cc" for three and four cylinder 4-stroke engines.

Ducati is an Italian motorcycle manufacturing company headquartered in Bologna, Italy. The company is directly owned by Italian automotive manufacturer Lamborghini, whose German parent company is Audi, itself owned by the Volkswagen Group.