Duet for One is a 1986 British drama film adapted from the play, a two-hander by Tom Kempinski, about a world-famous concert violinist named Stephanie Anderson who is suddenly struck with multiple sclerosis. It is set in London, and directed by Andrei Konchalovsky. The story was, at the time of the premiere of the play, assumed to be based on the life of cellist Jacqueline du Pré, who was diagnosed with MS, and her husband, conductor Daniel Barenboim, but Kempinski has stated that the subject of the play was a cathartic explosion of his own anxieties and depression.

A two-hander is a term for a play, film, or television programme with only two main characters. The two characters in question often display differences in social standing or experiences, differences that are explored and possibly overcome as the story unfolds. Instances of two-handers may include theatre, film, television episodes, television series, and radio.