The Duke–NUS Medical School (Duke–NUS) is a graduate medical school in Singapore. The school was set up in April 2005 as the Duke–NUS Graduate Medical School, Singapore's second medical school, after the Yong Loo Lin School of Medicine, and before the Lee Kong Chian School of Medicine. It is a collaboration between Duke University in the United States and the National University of Singapore in Singapore. Duke-NUS follows the American model of post-baccalaureate medical education, in which students begin their medical studies after earning a bachelor's degree. Students are awarded degrees from both Duke University and the National University of Singapore.

The Yong Loo Lin School of Medicine, established in 1905, is the first institution of higher learning in Singapore and the genesis of the National University of Singapore. The School is one of many who offer medical programmes in the Asia Pacific region. The Times Higher Education World University Rankings 2019 by subject and Quacquarelli Symonds (QS) World University Rankings by Subject 2019 list NUS Medicine as the leading medical school in Asia. Its distinguished alumni include cabinet ministers of Singapore, well-known doctors and a Prime Minister of Malaysia and father of the president-elect of Singapore.