The Duke Blue Devils men's lacrosse team represents Duke University in National Collegiate Athletic Association (NCAA) Division I men's lacrosse. Duke currently competes as a member of the Atlantic Coast Conference (ACC) and plays its home games at Koskinen Stadium in Durham, North Carolina. The principal rivalry of Duke is their all-sports nemesis North Carolina.

The Atlantic Coast Conference (ACC) is a collegiate athletic conference located in the United States. Headquartered in Charlotte, North Carolina, the ACC's fifteen member universities compete in the National Collegiate Athletic Association (NCAA)'s Division I. ACC football teams compete in the NCAA Division I Football Bowl Subdivision. The ACC sponsors competition in twenty-seven sports with many of its member institutions held in high regard nationally. Current members of the conference are: Boston College, Clemson, Duke, Florida State, Georgia Tech, Louisville, Miami, North Carolina, NC State, Notre Dame, Pittsburgh, Syracuse, Virginia, Virginia Tech, and Wake Forest.