Duke of Newcastle upon Tyne was a title that was created three times, once in the Peerage of England and twice in the Peerage of Great Britain. The first grant of the title was made in 1665 to William Cavendish, 1st Marquess of Newcastle upon Tyne. He was a prominent Royalist commander during the Civil War.

William Cavendish, 1st Duke of Newcastle upon Tyne, KG, KB, PC, who after 1665 styled himself as Prince William Cavendish, was an English courtier and supporter of the arts. He was a renowned horse breeder, as well as being patron of the playwright Ben Jonson and the intellectual group known as the Welbeck Circle.