Duraisamy Simon Lourdusamy was an Indian cardinal of the Catholic Church. He was the Prefect of the Congregation for the Oriental Churches in the Roman Curia and was elevated to the cardinalate in 1985. His episcopical motto was Aedificare domum Dei which means "To build the house of God". He was the fourth cardinal from India and the first curial cardinal of Asia outside of the Middle East.

The Dicastery for the Eastern Churches, previously named Congregation for the Oriental Churches or Congregation for the Eastern Churches, is a dicastery of the Roman Curia responsible for contact with the Eastern Catholic churches for the sake of assisting their development and protecting their rights. It also maintains whole and entire in the one Catholic Church the heritage and canon law of the various Eastern Catholic traditions. It has exclusive authority over the following regions: Egypt and the Sinai Peninsula, Eritrea and northern Ethiopia, southern Albania and Bulgaria, Cyprus, Greece, Iran, Iraq, Lebanon, Israel, Syria, Jordan and Turkey, and also oversees jurisdictions based in Romania, Southern Italy, Hungary, India and Ukraine.