The Durand de la Penne class are two guided-missile destroyers operated by the Italian Navy. The design is an enlarged version of the Audace class, updated with diesel and gas turbine CODOG machinery and modern sensors. Four ships were planned but the second pair were cancelled when Italy joined the Horizon project.

A guided-missile destroyer (DDG) is a destroyer whose primary armament is guided missiles so they can provide anti-aircraft warfare screening for the fleet. The NATO standard designation for these vessels is DDG, while destroyers which have a primary gun armament or a small number of anti-aircraft missiles sufficient only for point-defense are designated DD. Nations vary in their use of destroyer D designation in their hull pennant numbering, either prefixing or dropping it altogether.