Durham is a city in Marion County, Kansas, United States. As of the 2020 census, the population of the city was 89. The city took its name from Durham cattle. It is located about 8.5 miles (14 km) north of Hillsboro on the west side of K-15 highway next to a railroad.

K-15 is a 257.141-mile-long (413.828 km) north–south state highway in the U.S. State of Kansas. Originating at the Oklahoma state line as a continuation of State Highway 18 and continuing to the Nebraska state line where it continues as Nebraska Highway 15. Throughout Kansas, it is signed as the Eisenhower Memorial Highway due to its route through Abilene, where the Eisenhower Memorial Museum and Library is located.