Durham is a railway station on the East Coast Main Line, which runs between London King's Cross and Edinburgh Waverley. The station, situated 14 miles 3 chains south of Newcastle, serves the cathedral city of Durham in County Durham, England. It is owned by Network Rail and managed by London North Eastern Railway.

The East Coast Main Line (ECML) is a 393-mile long (632 km) electrified railway between its southern terminus at London King's Cross station and Edinburgh Waverley via Peterborough, Doncaster, York, Darlington, Durham and Newcastle. The line is a key transport artery on the eastern side of Great Britain running broadly parallel to the A1 road. The main line acts as a 'spine' for several diverging branches, serving destinations such as Cambridge, Leeds, Hull, Sunderland and Lincoln, all with direct services to London. In addition, a few ECML services extend beyond Edinburgh to serve Glasgow Central, although the principal London-Glasgow route is the West Coast Main Line (WCML).