Dyess is a town in Mississippi County, Arkansas, United States. The town was founded as Dyess Colony in 1934 as part of the Roosevelt administration's agricultural relief and rehabilitation program. It was the largest agrarian community established by the federal government during the Great Depression. It was the boyhood home of country singer Johnny Cash. As of the 2020 census, the population of Dyess was 339, down from 410 in 2010.

Mississippi County is the easternmost county in the U.S. state of Arkansas. As of the 2020 census, the population was 40,685. There are two county seats, Blytheville and Osceola. The county is named for the Mississippi River which borders the county to the east. Mississippi County is part of the First Congressional District in Arkansas.