The Electronic Entertainment Expo 2016 was the 22nd E3, during which several hardware manufacturers and software developers and publishers from the video game industry presented new and upcoming products to the attendees, primarily retailers and members of the video game press. The event, organized by the Entertainment Software Association, took place at the Los Angeles Convention Center from June 14–16, 2016. Approximately 50,300 people attended the event, slightly down from the previous year's. With video game consoles currently a couple years into their 8th generation, the focus of E3 2016 was primarily on new software titles, with new hardware revisions and auxiliary equipment to support the growing market sectors of 4K resolution displays and virtual reality headsets.

E3 was an annual trade event for the video game industry organized and presented by the Entertainment Software Association (ESA). It was held principally in Los Angeles from 1995 to 2019, with its final iteration held virtually in 2021. The event hosted developers, publishers, hardware manufacturers, and other industry professionals who used the occasion to introduce and advertise upcoming games, hardware, and merchandise to the press. During its existence, E3 was the world's largest and most prestigious annual gaming expo.