ELIZA is an early natural language processing computer program developed from 1964 to 1967 at MIT by Joseph Weizenbaum. Created to explore communication between humans and machines, ELIZA simulated conversation by using a pattern matching and substitution methodology that gave users an illusion of understanding on the part of the program, but had no representation that could be considered really understanding what was being said by either party. Whereas the ELIZA program itself was written (originally) in MAD-SLIP, the pattern matching directives that contained most of its language capability were provided in separate "scripts", represented in a lisp-like representation. The most famous script, DOCTOR, simulated a psychotherapist of the Rogerian school, and used rules, dictated in the script, to respond with non-directional questions to user inputs. As such, ELIZA was one of the first chatterbots and one of the first programs capable of attempting the Turing test.

Eliza is a visual novel game developed by Zachtronics, released on Windows, macOS, and Linux on August 12, 2019, with a Nintendo Switch version on October 10, 2019.