The EMD F45 is a C-C cowled diesel-electric locomotive built by General Motors Electro-Motive Division between 1968 and 1971. Power was provided by an EMD 645E3 20-cylinder engine which generated 3,600 hp (2,680 kW).

The passenger locomotives derivatives of the General Motors EMD GP40 diesel-electric locomotive have been, and continue to be, used by multiple passenger railroads in North America. For passenger service, the locomotives required extra components for providing steam or head-end power (HEP) for heating, lighting and electricity in passenger cars. Most of these passenger locomotives were rebuilt from older freight locomotives, while some were built as brand new models.