E is a 2006 Indian Tamil-language medical thriller film directed by S. P. Jananathan. The film stars Jiiva and Nayanthara, while Ashish Vidyarthi, Pasupathy and Karunas played supporting roles. The film's music is composed by director Srikanth Deva. The film was a commercial failure but received mixed-to-positive reviews.

S. P. Jananathan was an Indian film director and screenwriter who worked in Tamil cinema.