East Boston High School is a public high school located in the neighborhood of East Boston in Boston, Massachusetts. Specifically, the school is situated in the Eagle Hill Historic District. East Boston High is part of the Boston Public Schools system.

East Boston, nicknamed Eastie, is a neighborhood of Boston, Massachusetts, United States that was annexed by the city of Boston in 1637. Neighboring communities include Winthrop, Revere, and Chelsea. It is separated from the Boston neighborhood of Charlestown and downtown Boston by Boston Harbor. The footprint of the East Boston neighborhood as it is known today was created in the 1940s by connecting five of the inner harbor islands using land fill. Logan International Airport is located in East Boston, connecting Boston to domestic and international locations.