The East Los Angeles Interchange is an interchange complex located in Boyle Heights, Los Angeles, approximately 1 mile east of Downtown Los Angeles. With its southern portion handling over 550,000 vehicles per day, it is the busiest freeway interchange in the world. The northern portion, called the San Bernardino Split, is often considered a separate interchange. Four numbered routes converge at the interchange: Interstate 5 (I-5), I-10, U.S. Route 101 (US 101), and State Route 60 (SR 60), but the freeway segments shift alignments and directions.

Boyle Heights, historically known as Paredón Blanco, is a neighborhood in Los Angeles, California, located east of the Los Angeles River. It is one of the city's most notable and historic Chicano/Mexican-American communities and is known as a bastion of Chicano culture, hosting cultural landmarks like Mariachi Plaza and events like the annual Día de los Muertos celebrations.