East Palatka is a census-designated place (CDP) in Putnam County, Florida, United States. It is located on the east side of the City of Palatka at the intersection of U.S. Route 17/State Road 20/State Road 100 and the southwestern terminus of State Road 207. The population was 1,573 at the 2020 census, down from 1,654 at the 2010 census. It is part of the Palatka, Florida Micropolitan Statistical Area.

Putnam County is a county located in the northern part of the state of Florida. As of the 2020 census, the population was 73,321. Its county seat is Palatka.