East Palo Alto is a city in San Mateo County, California, United States. As of the 2020 census, the population of East Palo Alto was 30,034. It is situated on the San Francisco Peninsula, roughly halfway between the cities of San Francisco and San Jose. To the north and east is the San Francisco Bay, to the west is the city of Menlo Park, and to the south the city of Palo Alto. The city is directly north of Palo Alto. East Palo Alto was founded as an unincorporated community and incorporation in July 1983. The two cities are separated only by San Francisquito Creek and, largely, the Bayshore Freeway. The revitalization projects in 2000, and high income high-tech professionals moving into new developments, including employees from Google and Facebook, have begun to slowly eliminate the historically wide cultural and economic differences between the two cities. East Palo Alto and Palo Alto share both telephone area codes and postal ZIP codes.

The Sequoia Union High School District is a public union school district in the San Francisco Bay Area, primarily serving the southern San Mateo County communities of Atherton, Belmont, East Palo Alto, Ladera, San Carlos, Menlo Park, Portola Valley, Redwood City, and Woodside. The District currently serves more than 9,000 students, and also owns the radio station KCEA.